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AEG-1ΔMAC mouse

Info

Catalogue Number 154269
Antigen/Gene or Protein Targets Astrocyte Elevated Gene-1
Disease Keywords Hepatocellular Carcinogenesis, Chronic Inflammation
Model Conditional KO
Relevance Mouse model with conditional AEG-1 knockout in myeloid cells
Production Details Floxed AEG-1 mice (AEG-1fl/fl) in C57BL/6 background were crossed with LysM/Cre (B6.129P2-Lyz2tm1(cre)lfo/J
Conditional Yes
Conditional Description Conditional AEG-1ΔMAC knockout after single i.p. injection of 10µg/gm body weight of N-nitrosodiethylamine (DEN) given at 14 days of age followed by 0.05% phenobarbital daily in drinking water.
Growth/Phenotype Keywords Hepatocellular Carcinogenesis
Strain C57BL/6
Zygosity unknown
Research Area Cancer, Cell Signaling & Signal Transduction, Genetic Studies Tools, Immunology, Other

References

There are 2 reference entries for this reagent.

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References: 2 entries

Robertson et al. 2018. Cancer Res. 78(22):6436-6446. PMID: 30181179.

Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis.

Europe PMC ID: 30181179


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References: 2 entries

Robertson et al. 2018. Cancer Res. 78(22):6436-6446. PMID: 30181179.

Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis.


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