AEG-1ΔMAC mouse
Invented at Virginia Commonwealth University
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 154269 |
| Antigen/Gene or Protein Targets | Astrocyte Elevated Gene-1 |
| Disease Keywords | Hepatocellular Carcinogenesis, Chronic Inflammation |
| Model | Conditional KO |
| Relevance | Mouse model with conditional AEG-1 knockout in myeloid cells |
| Production Details | Floxed AEG-1 mice (AEG-1fl/fl) in C57BL/6 background were crossed with LysM/Cre (B6.129P2-Lyz2tm1(cre)lfo/J |
| Conditional | Yes |
| Conditional Description | Conditional AEG-1ΔMAC knockout after single i.p. injection of 10µg/gm body weight of N-nitrosodiethylamine (DEN) given at 14 days of age followed by 0.05% phenobarbital daily in drinking water. |
| Growth/Phenotype Keywords | Hepatocellular Carcinogenesis |
| Strain | C57BL/6 |
| Zygosity | unknown |
| Research Area | Cancer, Cell Signaling & Signal Transduction, Genetic Studies Tools, Immunology, Other |
References: 2 entries
Robertson et al. 2018. Cancer Res. 78(22):6436-6446. PMID: 30181179.
Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis.
Europe PMC ID: 30181179
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References: 2 entries
Robertson et al. 2018. Cancer Res. 78(22):6436-6446. PMID: 30181179.
Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis.
Add a reference
