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LNCaP androgen-independent cell line
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Catalogue Number 154164
Parental Line LNCaP
Host Human
Disease Keywords Human prostate adenocarcinoma
Model Tumour line
Relevance LNCaP cells are androgen-sensitive human prostate adenocarcinoma cells derived from the left supraclavicular lymph node metastasis from a 50-year-old Caucasian male in 1977. The androgen receptor (AR) in LNCaP cells harbours a T877A mutations which enables the anti-androgen flutamide to act as an agonist. This cell line is the most commonly used for prostate cancer research.
The cell line is a clonal population of LNCaP cells grown in steroid-depleted conditions for ~4 months. Cells adapted to growth conditions and are now routinely grown in media lacking testosterone
Production Details LNCaP cells grown in steroid-depleted conditions for ~4 months
Conditional No
Research Area Cancer
Recommended Growing Conditions RPMI-1640 + 10% FBS

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