Anti-p22phox [CS9]
Invented at Montana State University
- Datasheet
- References (6)
- Inventor Info
Info
| Catalogue Number | 154138 |
| Applications | WB |
| Antigen/Gene or Protein Targets | p22phox |
| Reactivity | Human |
| Relevance |
Monoclonal antibody which detects cytochrome b light chain. Background and Research Application p22phox protein, also known as the human neutrophil cytochrome b light chain (CYBA), is a heterodimeric integral membrane protein which is an essential component of the membrane-associated enzyme phagocyte NADPH-oxidase. Mutations in CYBA gene are known to cause autosomal recessive chronic granulomatous disease that is characterized by the failure of activated phagocytes to generate superoxide. Specific polymorphisms of the CYBA gene have also been identified that are associated with a decreased risk of coronary artery disease. |
| Host | Mouse |
| Immunogen | Partially purified human neutrophil flavocytochrome b |
| Immunogen UniProt ID | P13498 |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 21 kDa |
| Notes |
Production Details Purified using multi-step affinity chromatography with protein A. Storage Conditions Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles. Points of Interest Anti-p22phox (CS9) targets an epitope within 5 amino acids from the C-terminal region. Shows reactivity against human p22phox amino acids 165-169. Concentration 1mg/ml as standard |
| Research Area | Immunology |
References: 6 entries
Serwas et al. 2018. Front Immunol. 9:588. PMID: 29651288.
Noren Hooten et al. 2012. Arterioscler Thromb Vasc Biol. 32(11):2776-84. PMID: 22982460.
Taylor et al. 2007. Methods Mol Biol. 412:429-37. PMID: 18453126.
Immunoaffinity purification of human phagocyte flavocytochrome b and analysis of conformational dynamics.
Europe PMC ID: 18453126
Taylor et al. 2004. J Immunol. 173(12):7349-57. PMID: 15585859.
Site-specific inhibitors of NADPH oxidase activity and structural probes of flavocytochrome b: characterization of six monoclonal antibodies to the p22phox subunit.
Europe PMC ID: 15585859
Add a reference
References: 6 entries
Serwas et al. 2018. Front Immunol. 9:588. PMID: 29651288.
Noren Hooten et al. 2012. Arterioscler Thromb Vasc Biol. 32(11):2776-84. PMID: 22982460.
Taylor et al. 2007. Methods Mol Biol. 412:429-37. PMID: 18453126.
Immunoaffinity purification of human phagocyte flavocytochrome b and analysis of conformational dynamics.
Taylor et al. 2004. J Immunol. 173(12):7349-57. PMID: 15585859.
Site-specific inhibitors of NADPH oxidase activity and structural probes of flavocytochrome b: characterization of six monoclonal antibodies to the p22phox subunit.
Add a reference
