CHEC-9 immunomodulatory Peptide
Invented at Drexel University
- Datasheet
- References (9)
- Inventor Info
Info
| Catalogue Number | 154133 |
| Amino Acid Sequence | CHEASAAQC |
| Synonyms | Human neuroprotective polypeptide Diffusible Survival Evasion Peptide (DSEP) |
| Relevance | The CHEC-9 (peptide sequence CHEASAAQC) sequence is a fragment of a human diffusible survival evasion peptide (DSEP). CHEC-9 is an anti-inflammatory/neuroprotective peptide that uncompetitively binds and inhibit secreted phospholipase A2 (sPLA2). Allowing for the study of PLA2-directed inflammation of traumatic and autoimmune (Autoimmune Myeloencephalitis) neurodegenerative disorders. CHEC-9 also binds HSP70 and may influence HSP70-dependent dissolution of protein aggregates that accumulate in aging and disease models like Parkinson’s and Alzheimer’s Disease. |
| Research Area | Immunology, Neurobiology |
References: 9 entries
Cunningham et al. 2015. Rejuvenation Res. 18(2):136-44. PMID: 25485461.
Anti-inflammatory peptide regulates the supply of heat shock protein 70 monomers: implications for aging and age-related disease.
Europe PMC ID: 25485461
Secreted phospholipase A2 involvement in neurodegeneration: differential testing of prosurvival and anti-inflammatory effects of enzyme inhibition.
Europe PMC ID: 22720084
Chen et al. 2012. PLoS One. 7(6):e39257. PMID: 22720084.
Uncompetitive Phospholipase A2 Inhibition by CHEC Sequences Including Oral Treatment of Experimental Autoimmune Myeloencephalitis
Cunningham et al. 2006. J Neuroinflammation. 3:25. PMID: 16965626.
Inhibition of secreted phospholipase A2 by neuron survival and anti-inflammatory peptide CHEC-9.
Europe PMC ID: 16965626
Cunningham et al. 2004. J Neurotrauma. 21(11):1683-91. PMID: 15684658.
Systemic treatment of cerebral cortex lesions in rats with a new secreted phospholipase A2 inhibitor.
Europe PMC ID: 15684658
Add a reference
References: 9 entries
Cunningham et al. 2015. Rejuvenation Res. 18(2):136-44. PMID: 25485461.
Anti-inflammatory peptide regulates the supply of heat shock protein 70 monomers: implications for aging and age-related disease.
Secreted phospholipase A2 involvement in neurodegeneration: differential testing of prosurvival and anti-inflammatory effects of enzyme inhibition.
Chen et al. 2012. PLoS One. 7(6):e39257. PMID: 22720084.
Uncompetitive Phospholipase A2 Inhibition by CHEC Sequences Including Oral Treatment of Experimental Autoimmune Myeloencephalitis
Cunningham et al. 2006. J Neuroinflammation. 3:25. PMID: 16965626.
Inhibition of secreted phospholipase A2 by neuron survival and anti-inflammatory peptide CHEC-9.
Cunningham et al. 2004. J Neurotrauma. 21(11):1683-91. PMID: 15684658.
Systemic treatment of cerebral cortex lesions in rats with a new secreted phospholipase A2 inhibitor.
Add a reference
