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Anti NS1 [2H6] Monoclonal Antibody

Invented by Yee Joo Tan

Info

Catalogue Number 154121
Applications IF WB
Antigen/Gene or Protein Targets Non-structural protein 1 (NS1) of influenza A virus
Reactivity Mouse
Host Mouse
Immunogen GST-NS1 protein
Subclass IgG1
Recommended Growing Conditions Aliquot and store antibodies at -20C for prolonged usage
Strain Balb/c
Notes Influenza A virus, which belongs to the Orthomyxoviridae family, is a negative strand RNA virus and one of the rare RNA viruses to replicate in the nucleus. One of the viral proteins encoded by this virus is the non-structural protein 1 (NS1) which is essential for viral replication. It is a multifunctional protein that interacts with both RNA and host proteins. NS1 can reduce host translation by inhibiting the nuclear export of mature cellular mRNA via its interaction with the poly A tail. It also inhibits mRNA splicing by binding to the U6 small nuclear RNA. In addition, NS1 inhibits the antiviral activity of the interferon-induced pathway by binding to double-stranded RNAs that are generated during viral replication.
Research Area Microbiology, Other

References

There are 4 reference entries for this reagent.

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References: 4 entries

Wu et al. 2016. Sci Rep. 6:33382. PMID: 27633136.

Biochemical and structural characterization of the interface mediating interaction between the influenza A virus non-structural protein-1 and a monoclonal antibody.

Europe PMC ID: 27633136

Tan et al. 2010. J Med Virol. 82(3):467-75. PMID: 20087939.

A new panel of NS1 antibodies for easy detection and titration of influenza A virus.

Europe PMC ID: 20087939


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References: 4 entries

Wu et al. 2016. Sci Rep. 6:33382. PMID: 27633136.

Biochemical and structural characterization of the interface mediating interaction between the influenza A virus non-structural protein-1 and a monoclonal antibody.

Tan et al. 2010. J Med Virol. 82(3):467-75. PMID: 20087939.

A new panel of NS1 antibodies for easy detection and titration of influenza A virus.


Add a reference

Inventor Information