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Anti Ovarian Cancer Cells [A4] Monoclonal Antibody

Invented by Andre Choo

Info

Catalogue Number 154116
Applications N/A
Antigen/Gene or Protein Targets Human Embryonic Stem Cells, Ovarian Cancer Cells, Breast Cancer Cells
Synonyms Anti-hESC [A4], Anti-OC [A4], Anti-Breast Cancer Cells [A4]
Reactivity Human
Host Mouse
Immunogen HES-3 (Human Embryonic Stem cell line)
Subclass IgM
Notes Monoclonal antibody mAb-A4 against human embryonic stem cells (hESC), which also bound specifically to N-glycans present on 11 of 19 ovarian cancer (OC) and 8 of 14 breast cancer cell lines tested. Normal cell lines and tissue were unstained by mAb-A4.
The mAb-A4 epitopes were found to be Fucα1–2Galβ1–3GlcNAcβ (H type 1) and Galβ1–3GlcNAcβ (type 1 LacNAc). These structures were found to be present on multiple proteins from hESC and OC. The recognition of oncofetal H type 1 and type 1 LacNAc on OC by mAb-A4 is a novel and promising way to target OC and supports the theory that cancer can acquire stem-like phenotypes.
It is proposed that that the orthogonal framework used in this work could be the basis for advancing anti-glycan mAb characterization.
Research Area Cancer

References

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References: 1 entry

10.1074/jbc.M116.768887


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References: 1 entry

10.1074/jbc.M116.768887


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