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- References (2)
- Inventor Info
Info
| Catalogue Number | 153996 |
| Antigen/Gene or Protein Targets | lipoprotein receptor-related protein 1 |
| Synonyms | receptor-associated protein |
| Relevance | LRP1 is an endocytic receptor that interacts with several ligands including alpha 2-macroglobulin. Functionally, the receptor mediates cellular signalling with implications in Alzheimer's disease. This receptor is expressed in brain, liver, and lung and localized to the cytoplasm and nucleus. Expression of LRP1 requires RAP, a molecular chaperone of LRP1. |
| In vivo applications | inhibition of LRP1 function |
| In vitro applications | inhibition of LRP1 function |
| Research Area | Epigenetics & Nuclear Signalling, Cell Signaling & Signal Transduction, Neurobiology |
| Notes | This RAP molecule was engineered to resist pH and heat-induced denaturation via the addition of a disulfide bond within the D3 domain and elimination of key histidine residues. This stable RAP molecule does not disassociate from LRP1 under acidic conditions and thus functions as a potent LRP1 antagonist both in-vitro and in-vivo. |
References: 2 entries
Prasad et al. 2015. J Biol Chem. 290(28):17262-8. PMID: 26013822.
Generation of a Potent Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Antagonist by Engineering a Stable Form of the Receptor-associated Protein (RAP) D3 Domain.
Europe PMC ID: 26013822
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References: 2 entries
Prasad et al. 2015. J Biol Chem. 290(28):17262-8. PMID: 26013822.
Generation of a Potent Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Antagonist by Engineering a Stable Form of the Receptor-associated Protein (RAP) D3 Domain.
Add a reference
Inventor Information
Inventors
|
Dudley K. Strickland |
