- References (2)
- Inventor Info
|Antigen/Gene or Protein Targets||Omentin|
|Synonyms||Intelectin-1, ITLN1, hIntL-1|
|Reactivity||Human, Mouse and Rat|
Monoclonal antibody which detects omentin, linked to diabetes.
Background and Research Application
Omentin (human intelectin-1) is a secreted glycoprotein involved in the innate immune system as well as enhancing insulin-stimulated glucose uptake. Highly expressed in small intestine and adipose tissue and present at lower levels in testis, heart, pancreas, colon and skeletal muscle, intelectin-1 exists as a disulphide-linked homotrimer that functions to enhance insulin-stimulated glucose uptake and is also thought to participate in host defence against microorganisms. Serum levels of omentin are negatively correlated with obesity, suggesting a role in diabetes. More recently, omentin has been shown to interact with glycans on pathogenic bacteria.
|Immunogen UniProt ID||Q8WWA0|
|Molecular Weight (kDa)||120 kDa (trimer), 37 kDa (monomer)|
Purified using multi-step affinity chromatography with protein A.
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.
Points of Interest
Having conserved ligand binding site residues, both human and mouse intelectin-1 bind the exocyclic vicinal diol of carbohydrate ligands such as galactofuranose.
1mg/ml as standard
|Research Area||Bacteriology, Cardiovascular, Immunology, Metabolism, Microbiology|
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