Cancer Research Technology
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Catalogue Number 153965
Applications WB
Antigen/Gene or Protein Targets HPV E6
Reactivity Human papilloma virus
Relevance Nearly all cases of cervical cancer are associated with HPV infection, with two types, HPV16 and HPV18, present in 70% of cases. A defining feature of cervical cancers and derived cell lines is the continued expression of two viral oncoproteins, E6 and E7. A defining characteristic of E6 oncoproteins derived from cancer-causing HPV types is the presence of a PDZ binding motif (PBM) at the extreme carboxy terminus of the protein which is absent from E6 proteins derived from the so-called low-risk HPV types. Within this PBM is also a protein kinase A (PKA) phospho-acceptor site, which is thought to negatively regulate the association of E6 with its PDZ domain-containing substrates
Host Rabbit
Immunogen Peptide: RQERLQRRRETQV
Formulation Serum
Notes WB 1:500
Research Area Cancer

References

There are 4 reference entries for this reagent.

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References: 4 entries
RECENTLY UPDATED

Boon et al. 2015. J Virol. 89(3):1579-86. PMID: 25410862.

WB

Cancer-causing human papillomavirus E6 proteins display major differences in the phospho-regulation of their PDZ interactions.

Europe PMC ID: 25410862

Boon et al. 2013. J Virol. 87(3):1586-95. PMID: 23175360.

High-risk human papillomavirus E6 oncoproteins interact with 14-3-3ζ in a PDZ binding motif-dependent manner.

Europe PMC ID: 23175360


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References: 4 entries
RECENTLY UPDATED

Boon et al. 2015. J Virol. 89(3):1579-86. PMID: 25410862.

WB

Cancer-causing human papillomavirus E6 proteins display major differences in the phospho-regulation of their PDZ interactions.

Boon et al. 2013. J Virol. 87(3):1586-95. PMID: 23175360.

High-risk human papillomavirus E6 oncoproteins interact with 14-3-3ζ in a PDZ binding motif-dependent manner.


Add a reference