Anti-HPV-18 E6phospho, Polyclonal
Invented by Dr Lawrence Banks from International Centre For Genetic Engineering And Biotechnology (ICGEB)
Invented at International Centre For Genetic Engineering And Biotechnology (ICGEB)
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 153965 |
| Applications | WB |
| Antigen/Gene or Protein Targets | HPV E6 |
| Reactivity | Human papilloma virus |
| Relevance | Nearly all cases of cervical cancer are associated with HPV infection, with two types, HPV16 and HPV18, present in 70% of cases. A defining feature of cervical cancers and derived cell lines is the continued expression of two viral oncoproteins, E6 and E7. A defining characteristic of E6 oncoproteins derived from cancer-causing HPV types is the presence of a PDZ binding motif (PBM) at the extreme carboxy terminus of the protein which is absent from E6 proteins derived from the so-called low-risk HPV types. Within this PBM is also a protein kinase A (PKA) phospho-acceptor site, which is thought to negatively regulate the association of E6 with its PDZ domain-containing substrates |
| Host | Rabbit |
| Immunogen | Peptide: RQERLQRRRETQV |
| Formulation | Serum |
| Notes | WB 1:500 |
| Research Area | Cancer |
References: 4 entries
Boon et al. 2015. J Virol. 89(3):1579-86. PMID: 25410862.
WB
Cancer-causing human papillomavirus E6 proteins display major differences in the phospho-regulation of their PDZ interactions.
Europe PMC ID: 25410862
Boon et al. 2013. J Virol. 87(3):1586-95. PMID: 23175360.
High-risk human papillomavirus E6 oncoproteins interact with 14-3-3ζ in a PDZ binding motif-dependent manner.
Europe PMC ID: 23175360
Add a reference
References: 4 entries
Boon et al. 2015. J Virol. 89(3):1579-86. PMID: 25410862.
WB
Cancer-causing human papillomavirus E6 proteins display major differences in the phospho-regulation of their PDZ interactions.
Boon et al. 2013. J Virol. 87(3):1586-95. PMID: 23175360.
High-risk human papillomavirus E6 oncoproteins interact with 14-3-3ζ in a PDZ binding motif-dependent manner.
Add a reference
