Anti-p53, Polyclonal
Invented by Dr Lawrence Banks from International Centre For Genetic Engineering And Biotechnology (ICGEB)
Invented at International Centre For Genetic Engineering And Biotechnology (ICGEB)
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- References (4)
- Inventor Info
Info
| Catalogue Number | 153964 |
| Applications | IF IP WB |
| Antigen/Gene or Protein Targets | p53 |
| Synonyms | Tumour Protein p53, Cellular Tumour Antigen p53, Phosphoprotein p53, Antigen NY-CO-13 |
| Reactivity | Human |
| Relevance | p53 has been described as the 'guardian of the genome' because of its role in conserving stability by preventing genome mutation. The TP53 gene is the most frequently mutated gene (>50%) in human cancer. Rabbit anti-human p53 polyclonal recognises a 53kDa cytoplasmic/nuclear protein up regulated in response to DNA damage. |
| Host | Rabbit |
| Immunogen | C-terminal 14 amino acids of human p53 |
| Formulation | Serum |
| Molecular Weight (kDa) | 53kDa |
| Notes |
WB 1:1000 IF <1:2000 IP 0.3ul per sample |
| Research Area | Apoptosis and Programmed Cell Death, Cancer, Cell Signaling & Signal Transduction |
References: 4 entries
Thomas et al. 1999. Mol Cell Biol. 19(2):1092-100. PMID: 9891044.
Two polymorphic variants of wild-type p53 differ biochemically and biologically.
Europe PMC ID: 9891044
Thomas et al. 1996. Oncogene. 13(3):471-80. PMID: 8760288.
HPV-18 E6 inhibits p53 DNA binding activity regardless of the oligomeric state of p53 or the exact p53 recognition sequence.
Europe PMC ID: 8760288
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References: 4 entries
Thomas et al. 1999. Mol Cell Biol. 19(2):1092-100. PMID: 9891044.
Two polymorphic variants of wild-type p53 differ biochemically and biologically.
Thomas et al. 1996. Oncogene. 13(3):471-80. PMID: 8760288.
HPV-18 E6 inhibits p53 DNA binding activity regardless of the oligomeric state of p53 or the exact p53 recognition sequence.
Add a reference
