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E. coli Strain ALS1122
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Invented by Mark Eiteman

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Catalogue Number 153950
Antigen/Gene or Protein Targets Escherichia coli cells cannot metabolize glucose nor xylose.
Classification Escherichia coli
Bacterial Resistance N/A
Relevance Microbial fermentation processes are used to generate a myriad of comedic chemicals representing market segments valued in the billions of dollars. Microbial metabolic pathways are not though, naturally optimal for the generation of a desired chemical, rather they have evolved for the benefit of the organism. Metabolic engineering is the targeted and rational alteration of metabolism, and it involves the redirection of intra-cellular processes to generate a new product or a product in much higher yields and/or faster rates. UGA researchers have developed a collection of engineered E. coli strains that are capable of (i) producing pyruvate, (ii) used in the co-fermentation – at the same rate - of mixed pentoses and hexoses, or (iii) reducing the formation of acetate by-product of fermentations, under different metabolic conditions. These strains are optimal starting points for the development of novel derivative strains for industrial use
Genomic Feature MG1655 ΔptsG763::(FRT) ΔmanZ743::(FRT) Δglk-726::(FRT) ΔxylA748::(FRT) Δcrr-746::(FRT)
Notes Lysogeny broth: 10g/L tryptone, 10g/L NaCl, 5g/L yeast extract, pH adjusted to 7.0, aerobic 37C. Provided as lyophilized culture.
Research Area Metabolism, Microbiology, Bacteriology

References

There are 6 reference entries for this reagent.

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References: 6 entries

Xia et al. 2012. Microb Cell Fact. 11:77. PMID: 22691294.

Simultaneous utilization of glucose, xylose and arabinose in the presence of acetate by a consortium of Escherichia coli strains.

Europe PMC ID: 22691294

Lakshmanaswamy et al. 2011. J Ind Microbiol Biotechnol. 38(9):1477-84. PMID: 21225311.

Microbial removal of acetate selectively from sugar mixtures.

Europe PMC ID: 21225311

Eiteman et al. 2008. J Biol Eng. 2:3. PMID: 18304345.

A co-fermentation strategy to consume sugar mixtures effectively.

Europe PMC ID: 18304345


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References: 6 entries

Xia et al. 2012. Microb Cell Fact. 11:77. PMID: 22691294.

Simultaneous utilization of glucose, xylose and arabinose in the presence of acetate by a consortium of Escherichia coli strains.

Lakshmanaswamy et al. 2011. J Ind Microbiol Biotechnol. 38(9):1477-84. PMID: 21225311.

Microbial removal of acetate selectively from sugar mixtures.

Eiteman et al. 2008. J Biol Eng. 2:3. PMID: 18304345.

A co-fermentation strategy to consume sugar mixtures effectively.


Add a reference

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