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E. coli strain ALS1370
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Invented by Mark Eiteman

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Catalogue Number 153946
Antigen/Gene or Protein Targets Escherichia coli cells cannot metabolize glucose nor xylose.
Classification Escherichia coli
Bacterial Resistance N/A
Relevance Microbial fermentation processes are used to generate a myriad of comedic chemicals representing market segments valued in the billions of dollars. Microbial metabolic pathways are not though, naturally optimal for the generation of a desired chemical, rather they have evolved for the benefit of the organism. Metabolic engineering is the targeted and rational alteration of metabolism, and it involves the redirection of intra-cellular processes to generate a new product or a product in much higher yields and/or faster rates. UGA researchers have developed a collection of engineered E. coli strains that are capable of (i) producing pyruvate, (ii) used in the co-fermentation – at the same rate - of mixed pentoses and hexoses, or (iii) reducing the formation of acetate by-product of fermentations, under different metabolic conditions. These strains are optimal starting points for the development of novel derivative strains for industrial use
Genomic Feature C (ATCC8739) ptsG763::(FRT) manZ743::(FRT) glk-726::(FRT) crr-746::(FRT) xylA748::(FRT)
Notes Lysogeny broth: 10g/L tryptone, 10g/L NaCl, 5g/L yeast extract, pH adjusted to 7.0, aerobic 37C. Provided as lyophilized culture.
Research Area Metabolism, Microbiology, Bacteriology

References: 1 entry

Xia et al. 2012. Microb Cell Fact. 11:77. PMID: 22691294.


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References: 1 entry

Xia et al. 2012. Microb Cell Fact. 11:77. PMID: 22691294.


Add a reference

References: 1 entry

Xia et al. 2012. Microb Cell Fact. 11:77. PMID: 22691294.


Add a reference


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