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Anti-O-linked N-acetylglucosamine (O-GlcNAc) [6G3.A5]

Info

Catalogue Number 153902
Applications ELISA WB
Antigen/Gene or Protein Targets O-linked N-acetylglucosamine
Synonyms O-GlcNAc
Reactivity Mammals
Relevance The study of O-GlcNAc, a ubiquitous translation and transcription regulator which is found in a wide variety of proteins, is of great relevance to multiple chronic human and veterinary diseases. These include diabetes (and its effects in the heart, kidneys and eyes), cardiovascular disease, neurodegenerative disorders involving both plaque and tangle formation, inflammatory processes, liver disease, fibrosis, metabolic disorders and cancer. There is fast growing collection of evidence that O-GlcNAcylation plays a pivotal role in epigenetics.
Host Mouse
Immunogen Synthetic peptide O-GlcNAc
Subclass IgG2a
Notes This a 23 Mab panel was developed specifically to study the diverse roles of O-GlcNAc and that can be employed for detection, isolation, and site localization. For details on antigen strategy, please consult: Chin Fen Teo, et al., Nat Chem Biol. 2010 May; 6(5): 338-343. doi:10.1038/nchembio.338.
Research Area Cell Signaling & Signal Transduction, Metabolism, Cancer, Epigenetics & Nuclear Signalling, Gene Expression, Neurobiology

References

There are 4 reference entries for this reagent.

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References: 4 entries

Wade et al. 2016. NASN Sch Nurse. 31(2):90-3. PMID: 26822132.

Implementing 12345 Fit-Tastic: A Tool for Combating Childhood Obesity.

Europe PMC ID: 26822132

Teo et al. 2010. Nat Chem Biol. 6(5):338-43. PMID: 20305658.

Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc.

Europe PMC ID: 20305658


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References: 4 entries

Wade et al. 2016. NASN Sch Nurse. 31(2):90-3. PMID: 26822132.

Implementing 12345 Fit-Tastic: A Tool for Combating Childhood Obesity.

Teo et al. 2010. Nat Chem Biol. 6(5):338-43. PMID: 20305658.

Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc.


Add a reference

Inventor Information

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