|
Catalogue Number
|
153888 |
|
Applications
|
ELISA
WB
|
|
Antigen/Gene or Protein Targets
|
O-linked N-acetylglucosamine
|
|
Synonyms
|
O-GlcNAc
|
|
Reactivity
|
Mammals
|
|
Relevance
|
The study of O-GlcNAc, a ubiquitous translation and transcription regulator which is found in a wide variety of proteins, is of great relevance to multiple chronic human and veterinary diseases. These include diabetes (and its effects in the heart, kidneys and eyes), cardiovascular disease, neurodegenerative disorders involving both plaque and tangle formation, inflammatory processes, liver disease, fibrosis, metabolic disorders and cancer. There is fast growing collection of evidence that O-GlcNAcylation plays a pivotal role in epigenetics.
|
|
Host
|
Mouse
|
|
Immunogen
|
Synthetic peptide O-GlcNAc
|
|
Subclass
|
IgG2a
|
|
Notes
|
This a 23 Mab panel was developed specifically to study the diverse roles of O-GlcNAc and that can be employed for detection, isolation, and site localization. For details on antigen strategy, please consult: Chin Fen Teo, et al., Nat Chem Biol. 2010 May; 6(5): 338-343. doi:10.1038/nchembio.338.
|
|
Research Area
|
Cell Signaling & Signal Transduction, Metabolism, Cancer, Epigenetics & Nuclear Signalling, Gene Expression, Neurobiology
|
