Cancer Research Technology
Log in Register
Menu

SOD2 Cell Line

Invented by Fredrick Domann

Info

Catalogue Number 153875
Antigen/Gene or Protein Targets Superoxide dismutase 2
Parental Line HEK293T
Synonyms SOD2
Relevance The SOD2-null HEK293T cell line is the first known human cell line that completely lacks the enzyme responsible for removing mitochondrial superoxide generated during respiration. The resulting cells will provide an invaluable model for investigators across multiple disciplines as they search for ways to improve and boost mitochondrial function. This cell line has both basic research and translational research potential since many people have mitochondrial diseases and this new cell line will serve as an important model system to explore agents and treatments that can augment impaired mitochondrial function in multiple disciplines such as cancer, diabetes and metabolism.
Production Details Targeted gene editing by CRISPR/Cas9
Conditional No
Research Area Cancer, Cardiovascular, Drug Discovery & Development

References

There are 2 reference entries for this reagent.

View All References

References: 2 entries

Cramer-Morales et al. 2015. Free Radic Biol Med. 89:379-86. PMID: 26208779.

SOD2 targeted gene editing by CRISPR/Cas9 yields Human cells devoid of MnSOD.

Europe PMC ID: 26208779


Add a reference

References: 2 entries

Cramer-Morales et al. 2015. Free Radic Biol Med. 89:379-86. PMID: 26208779.

SOD2 targeted gene editing by CRISPR/Cas9 yields Human cells devoid of MnSOD.


Add a reference

Inventor Information