Anti-Tumor Necrosis Factor (TNF-α) [12F6]
Invented at University of Georgia
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 153869 |
| Applications | ELISA IP WB |
| Antigen/Gene or Protein Targets | Tumor Necrosis Factor- alpha |
| Synonyms | TNF-α |
| Reactivity | Horse |
| Relevance | Tumor necrosis factor is a cell signaling protein or cytokine that is involved in inflammation, and specifically one of the proteins in the acute phase reaction. TNF is produced mainly by macrophages but other white cells too. Some of its roles are to induce fever, apoptotic cell death, inhibit tumorigenesis and inflammation. Diseases associated with dysregulation of TNF production include inflammatory bowel disease (IBD), Psoriasis, Alzheimer's and cancer. |
| Host | Mouse |
| Immunogen | Protein |
| Subclass | IgG2b |
| Notes | Validated for use in WB and ELISA. Some cross-reactivity observed with rHTNFα. None with nETNFß, nMTNFα, rMTNFß and rPTNFα |
| Research Area | Apoptosis and Programmed Cell Death, Cell Signaling & Signal Transduction |
References: 2 entries
Su et al. 1992. Hybridoma. 11(6):715-27. PMID: 1284121.
Equine tumor necrosis factor alpha: cloning and expression in Escherichia coli, generation of monoclonal antibodies, and development of a sensitive enzyme-linked immunosorbent assay.
Europe PMC ID: 1284121
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References: 2 entries
Su et al. 1992. Hybridoma. 11(6):715-27. PMID: 1284121.
Equine tumor necrosis factor alpha: cloning and expression in Escherichia coli, generation of monoclonal antibodies, and development of a sensitive enzyme-linked immunosorbent assay.
Add a reference
