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Catalogue Number 153817
Backbone Size (bp) 6271
Bacterial Resistance Ampicillin
Vector Type pFLAG-CMV4
Synonyms TARDBP, TAR DNA Binding Protein, TDP-43, TAR DNA-Binding Protein 43, ALS10
Antigen/Gene or Protein Targets Mutant TDP43 not able to bind RNA
Relevance The TAR DNA-binding protein (TDP-43) is a highly conserved heterogeneous nuclear ribonucleoprotein (hnRNP) that controls the transcription, splicing and RNA stability of specific genes. The protein associates with single-stranded RNA and DNA sequences, and exhibits remarkable specificity for UG/TG dinucleotide repeats. Regulation of the human low-molecular-weight neurofilament (hNFL) by TDP-43 has also been reported to occur through 3′ UTR recruitment. TDP-43 is the major protein in inclusions from patients suffering from frontotemporal lobar degeneration (FTLD) with ubiquitin-positive inclusions and amyotrophic lateral sclerosis (ALS). The TAR DNA-binding protein (TDP-43) is a highly conserved heterogeneous nuclear ribonucleoprotein (hnRNP) that controls the transcription, splicing and RNA stability of specific genes. The protein associates with single-stranded RNA and DNA sequences, and exhibits remarkable specificity for UG/TG dinucleotide repeats. Regulation of the human low-molecular-weight neurofilament (hNFL) by TDP-43 has also been reported to occur through 3′ UTR recruitment. TDP-43 is the major protein in inclusions from patients suffering from frontotemporal lobar degeneration (FTLD) with ubiquitin-positive inclusions and amyotrophic lateral sclerosis (ALS).
Research Area Gene Expression, Neurobiology, Virology
Notes Concentration 1.2mg/ml

References

There are 2 reference entries for this reagent.

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References: 2 entries
RECENTLY UPDATED

Ayala et al. 2008. J Cell Sci. 121(Pt 22):3778-85. PMID: 18957508.

Structural determinants of the cellular localization and shuttling of TDP-43.

Europe PMC ID: 18957508


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References: 2 entries
RECENTLY UPDATED

Ayala et al. 2008. J Cell Sci. 121(Pt 22):3778-85. PMID: 18957508.

Structural determinants of the cellular localization and shuttling of TDP-43.


Add a reference