CMV4pFlagSiR TDP43 F4L Vector
Invented by Prof Emanuele Buratti from International Centre For Genetic Engineering And Biotechnology (ICGEB)
Invented at International Centre For Genetic Engineering And Biotechnology (ICGEB)
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 153817 |
| Backbone Size (bp) | 6271 |
| Bacterial Resistance | Ampicillin |
| Vector Type | pFLAG-CMV4 |
| Synonyms | TARDBP, TAR DNA Binding Protein, TDP-43, TAR DNA-Binding Protein 43, ALS10 |
| Antigen/Gene or Protein Targets | Mutant TDP43 not able to bind RNA |
| Relevance | The TAR DNA-binding protein (TDP-43) is a highly conserved heterogeneous nuclear ribonucleoprotein (hnRNP) that controls the transcription, splicing and RNA stability of specific genes. The protein associates with single-stranded RNA and DNA sequences, and exhibits remarkable specificity for UG/TG dinucleotide repeats. Regulation of the human low-molecular-weight neurofilament (hNFL) by TDP-43 has also been reported to occur through 3′ UTR recruitment. TDP-43 is the major protein in inclusions from patients suffering from frontotemporal lobar degeneration (FTLD) with ubiquitin-positive inclusions and amyotrophic lateral sclerosis (ALS). The TAR DNA-binding protein (TDP-43) is a highly conserved heterogeneous nuclear ribonucleoprotein (hnRNP) that controls the transcription, splicing and RNA stability of specific genes. The protein associates with single-stranded RNA and DNA sequences, and exhibits remarkable specificity for UG/TG dinucleotide repeats. Regulation of the human low-molecular-weight neurofilament (hNFL) by TDP-43 has also been reported to occur through 3′ UTR recruitment. TDP-43 is the major protein in inclusions from patients suffering from frontotemporal lobar degeneration (FTLD) with ubiquitin-positive inclusions and amyotrophic lateral sclerosis (ALS). |
| Research Area | Gene Expression, Neurobiology, Virology |
| Notes | Concentration 1.2mg/ml |
References: 2 entries
Ayala et al. 2008. J Cell Sci. 121(Pt 22):3778-85. PMID: 18957508.
Structural determinants of the cellular localization and shuttling of TDP-43.
Europe PMC ID: 18957508
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References: 2 entries
Ayala et al. 2008. J Cell Sci. 121(Pt 22):3778-85. PMID: 18957508.
Structural determinants of the cellular localization and shuttling of TDP-43.
Add a reference
