IAHF Intralobular Human Fibroblast Cell Line
Invented by Mikkel Morsing , Lone Rønnov-Jessen
Invented at University of Copenhagen
- References (2)
- Inventor Info
|Synonyms||"IAHF Intralobular Human Fibroblast Cell Line", "CD105high/CD26low lobular fibroblasts"|
|Disease Keywords||Breast Cancer|
CD105high/CD26low lobular fibroblasts have been shown to grow in culture maintaining its CD105/CD26 phenotype and functional distinction.
Furthermore, the CD105high/CD26low lobular fibroblasts are distinguished by their capacity to differentiate into adipogenic and osteogenic lineages.
Moreover, upon exposure to serum originally shown to reveal myofibroblastic differentiation in normal breast fibroblasts, the gene expression profile of CD105high/CD26low partly overlaps with the profile of breast tumor stoma.
|Notes||Keywords: Breast, Epithelial morphogenesis, Fibroblasts, Mesenchymal stem cells|
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