Anti-Integrin Beta 3a (GPIIIa, CD61) [ AP-5]
Invented at Versiti Blood Research Institute
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 153747 |
| Applications | FACS IHC WB |
| Antigen/Gene or Protein Targets | Integrin Beta 3a (GPIIIa, CD61) |
| Synonyms | CD-61 |
| Reactivity | Human |
| Relevance | Glycoprotein IIb/IIIa, also known as integrin aIIbß3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder. |
| Host | Mouse |
| Immunogen | peptide |
| Subclass | IgG1 |
| Molecular Weight (kDa) | ~ 86-87 kDa |
| Notes | Epitope - PSI domain (AA1-6) |
| Research Area | Immunology |
References: 2 entries
Honda et al. 1995. J Biol Chem. 270(20):11947-54. PMID: 7538128.
Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunit.
Europe PMC ID: 7538128
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References: 2 entries
Honda et al. 1995. J Biol Chem. 270(20):11947-54. PMID: 7538128.
Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunit.
Add a reference
