Anti-Integrin Beta 3a (GPIIIa, CD61) [AP-3]
Invented at Versiti Blood Research Institute
- Datasheet
- References (3)
- Inventor Info
Info
| Catalogue Number | 153746 |
| Applications | ELISA FACS |
| Antigen/Gene or Protein Targets | Integrin Beta 3a (GPIIIa, CD61) |
| Synonyms | CD-61 |
| Reactivity | N/A |
| Relevance |
Monoclonal antibody specific for human glycoprotein IIIa. Background and Research Application Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Glycoprotein IIb/IIIa, also known as integrin aIIbß3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrinogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder. This antibody is specific for amino acids 50-62 of GP11a. |
| Host | Mouse |
| Immunogen | Human platelet |
| Immunogen UniProt ID | P05106 |
| Subclass | IgG1 |
| Molecular Weight (kDa) | ~ 86-87 kDa |
| Notes |
Production Details Purified using multi-step affinity chromatography with protein A. Storage Conditions Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles. Points of Interest Research using this antibody has suggested that alpha 3A beta 1 may be a secondary receptor with post-cell-adhesion functions for a broad spectrum of extracellular matrices. PSI/Hybrid (amino acids 50-62) Concentration 1mg/ml as standard |
| Research Area | Immunology |
References: 3 entries
Faralli et al. 2019. Invest Ophthalmol Vis Sci. 60(5):1776-1788. PMID: 31022732.
Faralli et al. 2018. PLoS One. 13(3):e0192665. PMID: 29499052.
Peterson et al. 2008. Blood. 111(3):1234-9. PMID: 17959856.
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References: 3 entries
Faralli et al. 2019. Invest Ophthalmol Vis Sci. 60(5):1776-1788. PMID: 31022732.
Faralli et al. 2018. PLoS One. 13(3):e0192665. PMID: 29499052.
Peterson et al. 2008. Blood. 111(3):1234-9. PMID: 17959856.
Add a reference
