- References (3)
- Inventor Info
|Antigen/Gene or Protein Targets||Integrin Beta 3a (GPIIIa, CD61)|
Monoclonal antibody specific for human glycoprotein IIIa.
Background and Research Application
Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells.
Glycoprotein IIb/IIIa, also known as integrin aIIbß3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrinogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder.
This antibody is specific for amino acids 50-62 of GP11a.
|Immunogen UniProt ID||P05106|
|Molecular Weight (kDa)||~ 86-87 kDa|
Purified using multi-step affinity chromatography with protein A.
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.
Points of Interest
Research using this antibody has suggested that alpha 3A beta 1 may be a secondary receptor with post-cell-adhesion functions for a broad spectrum of extracellular matrices.
PSI/Hybrid (amino acids 50-62)
1mg/ml as standard
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