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Anti-Integrin Beta 3a (GPIIIa, CD61)  [AP-3]

Info

Catalogue Number 153746
Applications ELISA FACS
Antigen/Gene or Protein Targets Integrin Beta 3a (GPIIIa, CD61) 
Synonyms CD-61
Reactivity N/A
Relevance Monoclonal antibody specific for human glycoprotein IIIa.

Background and Research Application
Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells.
Glycoprotein IIb/IIIa, also known as integrin aIIbß3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrinogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder.
This antibody is specific for amino acids 50-62 of GP11a.
Host Mouse
Immunogen Human platelet
Immunogen UniProt ID P05106
Subclass IgG1
Molecular Weight (kDa) ~ 86-87 kDa
Notes Production Details
Purified using multi-step affinity chromatography with protein A.

Storage Conditions
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.

Points of Interest
Research using this antibody has suggested that alpha 3A beta 1 may be a secondary receptor with post-cell-adhesion functions for a broad spectrum of extracellular matrices.

PSI/Hybrid (amino acids 50-62)

Concentration
1mg/ml as standard
Research Area Immunology

References

There are 3 reference entries for this reagent.

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References: 3 entries

Faralli et al. 2019. Invest Ophthalmol Vis Sci. 60(5):1776-1788. PMID: 31022732.

Faralli et al. 2018. PLoS One. 13(3):e0192665. PMID: 29499052.

Peterson et al. 2008. Blood. 111(3):1234-9. PMID: 17959856.


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References: 3 entries

Faralli et al. 2019. Invest Ophthalmol Vis Sci. 60(5):1776-1788. PMID: 31022732.

Faralli et al. 2018. PLoS One. 13(3):e0192665. PMID: 29499052.

Peterson et al. 2008. Blood. 111(3):1234-9. PMID: 17959856.


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Inventor Information

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