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J558L Cell Line secreting OX40L

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Catalogue Number 153661
Antigen/Gene or Protein Targets Murine OX40L
Parental Line J558L - mammalian plasmacytoma cell line
Synonyms OX40L ligand, CD134, dendritic cells, DCs, Th2, CD525, systemic lupus erythematosus, TXGP1, OX-40L, gp34, TNFSF4, CD4 T cells, cytokine, Tumor necrosis factor receptor superfamily member 4, TNFRSF4
Host Mouse
Relevance OX40 receptor also known as CD134, a member of the tumor necrosis factor receptor superfamily of receptors, is not constitutively expressed on resting naive T cells. OX40 is activated 24 to 72 hours after binding to its ligand; OX40L, and is a secondary co-stimulatory immune checkpoint molecule. Expression of OX40 is dependent on full activation of the CD28 absent-T cell.
Production Details Primers specific to the murine sequence of the OX40L gene were used to generate a cDNA amplicon which was cloned into an expression vector. The vector has resistant markers to ampicillin and histidinol, and also contains promoters and enhancers for murine B-cells and plasma cells. A chimeric IgG1 and OX40 molecule with a 3' splice donor site was generated by subcloning the OX40L amplicon into a human IgG1 expression vector.
Conditional No
Research Area Immunology

References: 2 entries

Flynn et al. 1998. J Exp Med. 188(2):297-304. PMID: 9670042.

CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1.

Europe PMC ID: 9670042


Add a reference

References: 2 entries

Flynn et al. 1998. J Exp Med. 188(2):297-304. PMID: 9670042.

CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1.

Europe PMC ID: 9670042


Add a reference

References: 2 entries

Flynn et al. 1998. J Exp Med. 188(2):297-304. PMID: 9670042.

CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1.


Add a reference


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