Cancer Research Technology
Log in Register
Menu

Anti-Omomyc [21-1-3]

Invented by Laura Soucek at Vall D'Hebron Institute Of Oncology (VHIO)

Info

Catalogue Number 153657
Applications ELISA IHC IF WB
Antigen/Gene or Protein Targets Omomyc
Reactivity Human
Relevance Monoclonal antibody specific for Omomyc, capable of suppressing Myc-induced oncogenesis.

Background and Research Application
Omomyc is a dominant-negative allele of the proto-oncogene Myc (c-Myc). Omomyc is a mutant bHLHZip domain that sequesters Myc in complexes that are unable to bind to the E box recognition element and activate transcription but remain competent for transcriptional repression. Expression of omomyc can induce rapid tumour regression in mouse models with little toxicity for normal tissues, acting as a suppressor of Myc-induced oncogenesis.
Host Mouse
Subclass IgG2a kappa
Notes Production Details
Purified using multi-step affinity chromatography with protein A.

Storage Conditions
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.

Concentration
1mg/ml as standard
Research Area Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, Gene Expression

References

There are 6 reference entries for this reagent.

View All References

References: 6 entries

Fiorentino et al. 2016. Oncotarget. 7(21):31014-28. PMID: 27105536.

Growth suppression by MYC inhibition in small cell lung cancer cells with TP53 and RB1 inactivation.

Europe PMC ID: 27105536

Soucek et al. 2013. Genes Dev. 27(5):504-13. PMID: 23475959.

Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice.

Europe PMC ID: 23475959

Soucek et al. 2004. Cell Death Differ. 11(9):1038-45. PMID: 15143346.

Omomyc expression in skin prevents Myc-induced papillomatosis.

Europe PMC ID: 15143346


Add a reference

References: 6 entries

Fiorentino et al. 2016. Oncotarget. 7(21):31014-28. PMID: 27105536.

Growth suppression by MYC inhibition in small cell lung cancer cells with TP53 and RB1 inactivation.

Soucek et al. 2013. Genes Dev. 27(5):504-13. PMID: 23475959.

Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice.

Soucek et al. 2004. Cell Death Differ. 11(9):1038-45. PMID: 15143346.

Omomyc expression in skin prevents Myc-induced papillomatosis.


Add a reference