Anti-Omomyc [21-1-3]
Invented by Laura Soucek
Invented at Vall D'Hebron Institute Of Oncology (VHIO)
- Datasheet
- References (6)
- Inventor Info
Info
![Protein extracts of U87-MG glioblastoma cells with Doxycycline-inducible vectors for Omomyc-RFP and Omomyc were probed with anti-Omomyc [21-1-3]. Purified antibody is at 7.3 mg/ml.](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/3385d993-9948-4251-b00c-6f6145db3e82.png)
![A549 cells with Doxycycline-inducible Omomyc were orthotopically implanted into recipient mice. After treatment with Doxycycline,
lung tissue was collected and FFPE lung sections were stained with anti-Omomyc monoclonal [21-1-3].](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/d10fdd3b-ff00-44e1-b157-e597857f37da.png)
![FFPE pancreas sections from transgenic mice expressing Omomyc were stained with anti-Omomyc monoclonal antibody [21-1-3].](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/6721026c-8e37-4742-ab8b-d13489845eea.png)
![Protein extracts of U87-MG glioblastoma cells with Doxycycline-inducible vectors for Omomyc-RFP and Omomyc were probed with anti-Omomyc [21-1-3]. Purified antibody is at 7.3 mg/ml.](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/3385d993-9948-4251-b00c-6f6145db3e82.png)
![A549 cells with Doxycycline-inducible Omomyc were orthotopically implanted into recipient mice. After treatment with Doxycycline,
lung tissue was collected and FFPE lung sections were stained with anti-Omomyc monoclonal [21-1-3].](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/d10fdd3b-ff00-44e1-b157-e597857f37da.png)
![FFPE pancreas sections from transgenic mice expressing Omomyc were stained with anti-Omomyc monoclonal antibody [21-1-3].](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/6721026c-8e37-4742-ab8b-d13489845eea.png)
![Image thumbnail for Anti-Omomyc [21-1-3]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/3385d993-9948-4251-b00c-6f6145db3e82.png)
![Image thumbnail for Anti-Omomyc [21-1-3]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/d10fdd3b-ff00-44e1-b157-e597857f37da.png)
![Image thumbnail for Anti-Omomyc [21-1-3]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/6721026c-8e37-4742-ab8b-d13489845eea.png)
![Image thumbnail for Anti-Omomyc [21-1-3]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/77d9777a-cfcd-4f08-8896-ca1ba2329cdb.png)
![Image thumbnail for Anti-Omomyc [21-1-3]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/6eec0aa6-aeca-44bc-9c40-074593053152.png)
| Catalogue Number | 153657 |
| Applications | ELISA IHC IF WB |
| Antigen/Gene or Protein Targets | Omomyc |
| Reactivity | Human |
| Relevance |
Monoclonal antibody specific for Omomyc, capable of suppressing Myc-induced oncogenesis. Background and Research Application Omomyc is a dominant-negative allele of the proto-oncogene Myc (c-Myc). Omomyc is a mutant bHLHZip domain that sequesters Myc in complexes that are unable to bind to the E box recognition element and activate transcription but remain competent for transcriptional repression. Expression of omomyc can induce rapid tumour regression in mouse models with little toxicity for normal tissues, acting as a suppressor of Myc-induced oncogenesis. |
| Host | Mouse |
| Subclass | IgG2a kappa |
| Notes |
Production Details Purified using multi-step affinity chromatography with protein A. Storage Conditions Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles. Concentration 1mg/ml as standard |
| Research Area | Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, Gene Expression |
References: 6 entries
Fiorentino et al. 2016. Oncotarget. 7(21):31014-28. PMID: 27105536.
Growth suppression by MYC inhibition in small cell lung cancer cells with TP53 and RB1 inactivation.
Europe PMC ID: 27105536
Soucek et al. 2013. Genes Dev. 27(5):504-13. PMID: 23475959.
Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice.
Europe PMC ID: 23475959
Soucek et al. 2004. Cell Death Differ. 11(9):1038-45. PMID: 15143346.
Omomyc expression in skin prevents Myc-induced papillomatosis.
Europe PMC ID: 15143346
Add a reference
References: 6 entries
Fiorentino et al. 2016. Oncotarget. 7(21):31014-28. PMID: 27105536.
Growth suppression by MYC inhibition in small cell lung cancer cells with TP53 and RB1 inactivation.
Soucek et al. 2013. Genes Dev. 27(5):504-13. PMID: 23475959.
Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice.
Soucek et al. 2004. Cell Death Differ. 11(9):1038-45. PMID: 15143346.
Omomyc expression in skin prevents Myc-induced papillomatosis.
Add a reference
Inventor Information
Inventors
|
Laura Soucek |
