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Monoclonal Antibodies

Anti-Inhibin α [PO12/8]

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Clone PO 12/8 used to stain prostate cancer cells and detect levels of inhibin α by IHC-P. INHα expression in clinical specimens and its association to prostate disease. Immunohistochemical staining of INHα in primary prostate tumours from PCa patients with (A–D) organ-confined (negative) and (E–H) metastatic disease (positive). Source: Balanathan et al. 2009. Br J Cancer. 100(11):1784-93. PMID: 19436293.
Clone PO 12/8 used to stain prostate cancer cells and detect levels of inhibin α by IHC-P. Immunostaining in biopsy specimens from men with prostate cancer in regions of non-malignant (a, c, e) or malignant (b, d, f) tissue... Panels e and f show the up-regulation of inhibin α subunit immunoreactivity in malignant compared to non-malignant regions of tissue using the monoclonal antibody, PO#12. Source: Risbridger et al. 2004. Mol Cell Endocrinol. 225(1-2):73-6. PMID: 15451570.
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Catalogue Number 153647
Applications ELISA IHC
Antigen/Gene or Protein Targets Inhibin α
Synonyms Inhibin alpha chain, INHA
Reactivity Human
Relevance Higher levels of inhibin α have been associated with a higher risk of cancer progression and recurrence. Clone PO 12/8 is useful in detecting inhibin α levels, especially in prostate cancer cells.
Host Mouse
Immunogen Synthetic peptide corresponding to epitope region aa73-96 of the αC region of α subunit of inhibin A
Positive Control Prostate tissue
Subclass IgG2a
Molecular Weight (kDa) 40
Myeloma Used Sp2/0-Ag14
Strain Balb/c
Notes Suggested dilutions for use

Immunohistochemistry 90 μg/ml
ELISA Assay-dependent

Research Areas: Endocrinology;Cancer;Fertility;Cell Signaling & Signal Transduction
Research Area Cancer, Cell Signaling & Signal Transduction

References

There are 6 reference entries for this reagent.

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References: 6 entries

Balanathan et al. 2009. Br J Cancer. 100(11):1784-93. PMID: 19436293.

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Elevated level of inhibin-alpha subunit is pro-tumourigenic and pro-metastatic and associated with extracapsular spread in advanced prostate cancer.

Europe PMC ID: 19436293

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Risbridger et al. 2004. Mol Cell Endocrinol. 225(1-2):73-6. PMID: 15451570.

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Re-evaluation of inhibin alpha subunit as a tumour suppressor in prostate cancer.

Europe PMC ID: 15451570

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Robertson et al. 2001. Mol Cell Endocrinol. 180(1-2):79-86. PMID: 11451575.

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Development of an inhibin alpha subunit ELISA with broad specificity.

Europe PMC ID: 11451575

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References: 6 entries

Balanathan et al. 2009. Br J Cancer. 100(11):1784-93. PMID: 19436293.

View  

Elevated level of inhibin-alpha subunit is pro-tumourigenic and pro-metastatic and associated with extracapsular spread in advanced prostate cancer.

View  

Risbridger et al. 2004. Mol Cell Endocrinol. 225(1-2):73-6. PMID: 15451570.

View  

Re-evaluation of inhibin alpha subunit as a tumour suppressor in prostate cancer.

View  

Robertson et al. 2001. Mol Cell Endocrinol. 180(1-2):79-86. PMID: 11451575.

View  

Development of an inhibin alpha subunit ELISA with broad specificity.

View  

Add a reference

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