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Anti-Myelin Basic Protein (region Thr98) [98/P12]

Info

Catalogue Number 153644
Applications ELISA WB
Antigen/Gene or Protein Targets Myelin Basic Protein (region Thr98)
Synonyms Myelin basic protein,
MBP, 20 kDa microtubule-stabilizing protein, Myelin A1 protein
Reactivity Human
Relevance The phosphorylation of myelin basic protein (MBP) has been shown to decrease the ability of MBP to aggregate lipid vesicles and consequently destabilising the compact structure of myelin, a destruction that has been observed in demyelinating diseases such as Multiple Sclerosis. (Yon, M et al. 1995) Clone 98/P12 is a useful detector of phosphorylated MBP by binding to Thr98 of human MBP in the phosphorylated state.
Host Mouse
Immunogen Synthetic peptide corresponding to human MBP when phosphorylated at threonine 98
Positive Control Brain tissue
Subclass IgG2a
Molecular Weight (kDa) 13-21
Myeloma Used Sp2/0-Ag14
Notes Suggested dilutions for use

Western Blot 1:1000-1:2000
Immunocytochemistry 1:400
ELISA Assay-dependent

Research Areas: Neurobiology; Cell Type or Organelle Marker; Immunology
Research Area Cell Type or Organelle Marker, Immunology, Neurobiology

References

There are 10 reference entries for this reagent.

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References: 10 entries

DeBruin et al. 2006. Biochem Cell Biol. 84(6):993-1005. PMID: 17215885.

Partitioning of myelin basic protein into membrane microdomains in a spontaneously demyelinating mouse model for multiple sclerosis.

Europe PMC ID: 17215885

DeBruin et al. 2005. J Neurosci Res. 80(2):211-25. PMID: 15772981.

Developmental partitioning of myelin basic protein into membrane microdomains.

Europe PMC ID: 15772981

Atkins et al. 1999. J Neurochem. 73(3):1090-7. PMID: 10461899.

Regulation of myelin basic protein phosphorylation by mitogen-activated protein kinase during increased action potential firing in the hippocampus.

Europe PMC ID: 10461899

Yon et al. 1996. J Neuroimmunol. 65(1):55-9. PMID: 8642064.

Identification of a mitogen-activated protein kinase site in human myelin basic protein in situ.

Europe PMC ID: 8642064

Yon et al. 1995. J Neuroimmunol. 58(2):121-9. PMID: 7759601.

Preparation of a novel monoclonal antibody specific for myelin basic protein phosphorylated on Thr98.

Europe PMC ID: 7759601


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References: 10 entries

DeBruin et al. 2006. Biochem Cell Biol. 84(6):993-1005. PMID: 17215885.

Partitioning of myelin basic protein into membrane microdomains in a spontaneously demyelinating mouse model for multiple sclerosis.

DeBruin et al. 2005. J Neurosci Res. 80(2):211-25. PMID: 15772981.

Developmental partitioning of myelin basic protein into membrane microdomains.

Atkins et al. 1999. J Neurochem. 73(3):1090-7. PMID: 10461899.

Regulation of myelin basic protein phosphorylation by mitogen-activated protein kinase during increased action potential firing in the hippocampus.

Yon et al. 1996. J Neuroimmunol. 65(1):55-9. PMID: 8642064.

Identification of a mitogen-activated protein kinase site in human myelin basic protein in situ.

Yon et al. 1995. J Neuroimmunol. 58(2):121-9. PMID: 7759601.

Preparation of a novel monoclonal antibody specific for myelin basic protein phosphorylated on Thr98.


Add a reference

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