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Anti-CYP450 Aromatase [H4]

Info

Catalogue Number 153638
Applications IHC IF WB
Antigen/Gene or Protein Targets CYP450 Aromatase
Synonyms Aromatase, CYPXIX, Cytochrome P-450AROM, Cytochrome P450 19A1, Estrogen synthase, CYP19A1, ARO1, CYAR, CYP19
Reactivity Human
Relevance CYP450 Aromatase is part of the CYP19A1 family involved in the aromatization of androgens to estrogens, a highly conserved mechanism amongst mammals. Clone H4 recognizes a conserved epitope on the CYP450 aromatase, allowing for detection of aromatase levels using various analysis methods.
Host Mouse
Immunogen Synthetic peptide corresponding to AAs 376-390 of human aromatase (KALEDDVIGYPVKK)
Subclass IgG2a
Positive Control Placenta
Molecular Weight (kDa) 55
Myeloma Used Sp2/0-Ag14
Strain Balb/c
Notes Suggested dilutions for use

Western Blot 1:50-1:5000
Immunohistochemistry 1:50-1:100
Immunofluorescence 1:100
Immunocytochemistry 1:75

Research Areas: Endocrinology;Cancer;Fertility;Veterinary Science
Research Area Cancer

References: 22 entries

Amanatullah et al. 2017. Breast Cancer Res. 19(1):121. PMID: 29141657.

Local estrogen axis in the human bone microenvironment regulates estrogen receptor-positive breast cancer cells.

Europe PMC ID: 29141657

Wilsher et al. 2013. Reproduction. 145(6):541-54. PMID: 23550169.

Ovarian and placental morphology and endocrine functions in the pregnant giraffe (Giraffa camelopardalis).

Europe PMC ID: 23550169

Campbell et al. 2012. Endocrinology. 153(9):4533-43. PMID: 22778215.

The role of anti-Müllerian hormone (AMH) during follicle development in a monovulatory species (sheep).

Europe PMC ID: 22778215

Mlodawska et al. 2010. Theriogenology. 74(9):1707-12. PMID: 20932560.

Immunohistochemical localization of aromatase during the development and atresia of ovarian follicles in prepubertal horses.

Europe PMC ID: 20932560

Catalano et al. 2010. J Biol Chem. 285(8):5581-93. PMID: 20026603.

Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells.

Europe PMC ID: 20026603

Sirianni et al. 2009. J Biol Chem. 284(42):28905-16. PMID: 19679653.

Inhibition of cyclooxygenase-2 down-regulates aromatase activity and decreases proliferation of Leydig tumor cells.

Europe PMC ID: 19679653

Rago et al. 2007. Reprod Biol Endocrinol. 5:23. PMID: 17553131.

Cytochrome P450arom, androgen and estrogen receptors in pig sperm.

Europe PMC ID: 17553131

Rago et al. 2005. Reprod Biol Endocrinol. 3:72. PMID: 16372909.

Cytochrome P450 aromatase expression in human seminoma.

Europe PMC ID: 16372909

Pakarainen et al. 2005. Mol Endocrinol. 19(10):2591-602. PMID: 15941853.

Knockout of luteinizing hormone receptor abolishes the effects of follicle-stimulating hormone on preovulatory maturation and ovulation of mouse graafian follicles.

Europe PMC ID: 15941853

Fazleabas et al. 2003. Fertil Steril. 80 Suppl 2:820-7. PMID: 14505759.

Steroid receptor and aromatase expression in baboon endometriotic lesions.

Europe PMC ID: 14505759

Turner et al. 2002. J Endocrinol. 172(1):21-30. PMID: 11786371.

Development and validation of a new monoclonal antibody to mammalian aromatase.

Europe PMC ID: 11786371


Add a reference

References: 22 entries

Amanatullah et al. 2017. Breast Cancer Res. 19(1):121. PMID: 29141657.

Local estrogen axis in the human bone microenvironment regulates estrogen receptor-positive breast cancer cells.

Europe PMC ID: 29141657

Wilsher et al. 2013. Reproduction. 145(6):541-54. PMID: 23550169.

Ovarian and placental morphology and endocrine functions in the pregnant giraffe (Giraffa camelopardalis).

Europe PMC ID: 23550169

Campbell et al. 2012. Endocrinology. 153(9):4533-43. PMID: 22778215.

The role of anti-Müllerian hormone (AMH) during follicle development in a monovulatory species (sheep).

Europe PMC ID: 22778215

Mlodawska et al. 2010. Theriogenology. 74(9):1707-12. PMID: 20932560.

Immunohistochemical localization of aromatase during the development and atresia of ovarian follicles in prepubertal horses.

Europe PMC ID: 20932560

Catalano et al. 2010. J Biol Chem. 285(8):5581-93. PMID: 20026603.

Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells.

Europe PMC ID: 20026603

Sirianni et al. 2009. J Biol Chem. 284(42):28905-16. PMID: 19679653.

Inhibition of cyclooxygenase-2 down-regulates aromatase activity and decreases proliferation of Leydig tumor cells.

Europe PMC ID: 19679653

Rago et al. 2007. Reprod Biol Endocrinol. 5:23. PMID: 17553131.

Cytochrome P450arom, androgen and estrogen receptors in pig sperm.

Europe PMC ID: 17553131

Rago et al. 2005. Reprod Biol Endocrinol. 3:72. PMID: 16372909.

Cytochrome P450 aromatase expression in human seminoma.

Europe PMC ID: 16372909

Pakarainen et al. 2005. Mol Endocrinol. 19(10):2591-602. PMID: 15941853.

Knockout of luteinizing hormone receptor abolishes the effects of follicle-stimulating hormone on preovulatory maturation and ovulation of mouse graafian follicles.

Europe PMC ID: 15941853

Fazleabas et al. 2003. Fertil Steril. 80 Suppl 2:820-7. PMID: 14505759.

Steroid receptor and aromatase expression in baboon endometriotic lesions.

Europe PMC ID: 14505759

Turner et al. 2002. J Endocrinol. 172(1):21-30. PMID: 11786371.

Development and validation of a new monoclonal antibody to mammalian aromatase.

Europe PMC ID: 11786371


Add a reference

References: 22 entries

Amanatullah et al. 2017. Breast Cancer Res. 19(1):121. PMID: 29141657.

Local estrogen axis in the human bone microenvironment regulates estrogen receptor-positive breast cancer cells.

Wilsher et al. 2013. Reproduction. 145(6):541-54. PMID: 23550169.

Ovarian and placental morphology and endocrine functions in the pregnant giraffe (Giraffa camelopardalis).

Campbell et al. 2012. Endocrinology. 153(9):4533-43. PMID: 22778215.

The role of anti-Müllerian hormone (AMH) during follicle development in a monovulatory species (sheep).

Mlodawska et al. 2010. Theriogenology. 74(9):1707-12. PMID: 20932560.

Immunohistochemical localization of aromatase during the development and atresia of ovarian follicles in prepubertal horses.

Catalano et al. 2010. J Biol Chem. 285(8):5581-93. PMID: 20026603.

Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells.

Sirianni et al. 2009. J Biol Chem. 284(42):28905-16. PMID: 19679653.

Inhibition of cyclooxygenase-2 down-regulates aromatase activity and decreases proliferation of Leydig tumor cells.

Rago et al. 2007. Reprod Biol Endocrinol. 5:23. PMID: 17553131.

Cytochrome P450arom, androgen and estrogen receptors in pig sperm.

Rago et al. 2005. Reprod Biol Endocrinol. 3:72. PMID: 16372909.

Cytochrome P450 aromatase expression in human seminoma.

Pakarainen et al. 2005. Mol Endocrinol. 19(10):2591-602. PMID: 15941853.

Knockout of luteinizing hormone receptor abolishes the effects of follicle-stimulating hormone on preovulatory maturation and ovulation of mouse graafian follicles.

Fazleabas et al. 2003. Fertil Steril. 80 Suppl 2:820-7. PMID: 14505759.

Steroid receptor and aromatase expression in baboon endometriotic lesions.

Turner et al. 2002. J Endocrinol. 172(1):21-30. PMID: 11786371.

Development and validation of a new monoclonal antibody to mammalian aromatase.


Add a reference


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