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pSIEW-RUNX1-EVI1 Vector

Info

Catalogue Number 153538
Backbone Size (bp) 14400
Bacterial Resistance Ampicillin
Vector Type pSIEW
Synonyms Runt Related Transcription Factor 1, RUXN1, AML1, AML1-EVI-1, AMLCR1, CBF2alpha, CBFA2, EVI-1, PEBP2aB, PEBP2alpha, acute myeloid leukemia 1 protein, core-binding factor subunit alpha-2
Antigen/Gene or Protein Targets RUNX1-EVI1 (chimeric gene)
Relevance Runt-related transcription factor 1, a protein that in humans is encoded by the RUNX1 gene, that regulates the differentiation of hematopoietic stem cells into mature blood cells and plays a major role in the development of the neurons that transmit pain.

It belongs to the RUNX family of genes also known as core binding factor-α, and RUNX proteins form heterodimeric complexes with these confering increased DNA binding and stability.

Chromosomal translocations involving RUNX1 are associated with several types of leukemia including M2 Acute myeloid leukaemia and DNA mutations are implicated in cases of breast cancer.
Research Area Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling

References

There are 2 reference entries for this reagent.

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References: 2 entries

Maki et al. 2008. Cancer Sci. 99(10):1878-83. PMID: 19016745.

Role of the RUNX1-EVI1 fusion gene in leukemogenesis.

Europe PMC ID: 19016745


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References: 2 entries

Maki et al. 2008. Cancer Sci. 99(10):1878-83. PMID: 19016745.

Role of the RUNX1-EVI1 fusion gene in leukemogenesis.


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