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Anti-TIGIT [13E7]

Info

Catalogue Number 153515
Applications ELISA IHC WB
Antigen/Gene or Protein Targets TIGIT
Synonyms T-cell immunoreceptor with Ig and ITIM domains, V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3
Reactivity Human and Mouse
Relevance Monoclonal antibody which detects TIGIT immunoglobulin protein.

Background and Research Application
TIGIT (also known as T cell immunoreceptor with Ig and ITIM domains) is a receptor on some percentage of T cells and Natural Killer Cells (NK). It is also identified as WUCAM and Vstm3. TIGIT binds with high affinity to the poliovirus receptor (PVR), also known as CD155, which causes increased secretion of IL-10 and decreased secretion of IL-12B and suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Research has shown that TIGIT-Fc fusion protein could interact with PVR on dendritic cells and increase its IL-10 secretion level/decrease its IL-12 secretion level under LPS stimulation, and also inhibit T cell activation in vivo. TIGIT's inhibition of NK cytotoxicity can be blocked by antibodies against its interaction with PVR and the activity is directed through its ITIM domain. TIGIT and PD-1 has been shown to be over expressed on tumour antigen-specific (TA-specific) CD8+ T cells and CD8+ tumour infiltrating lymphocytes (TILs) from individuals with melanoma.
Host Mouse
Immunogen UniProt ID Q495A1
Subclass IgG1
Notes Production Details
Purified using multi-step affinity chromatography with protein A.

Storage Conditions
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.

Points of Interest
Reacts with human formalin fixed paraffin tissue.

Concentration
1mg/ml as standard
Research Area Immunology

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