Anti-PD-1 [J110]
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Info
| Catalogue Number | 153513 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | PD-1 |
| Synonyms | Programmed cell death protein 1, CD279 |
| Reactivity | Human |
| Relevance |
The PD-1 protein is an inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors. PD-1 belongs to the immunoglobulin superfamily and is expressed on T cells and pro-B cells. PD-1 binds two ligands, PD-L1 and PD-L2. PD-1, functioning as an immune checkpoint, plays an important role in down regulating the immune system by preventing the activation of T-cells, which in turn reduces autoimmunity and promotes self-tolerance. The inhibitory effect of PD-1 is accomplished through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (suppressor T cells). A new class of drugs that block PD-1, the PD-1 inhibitors, activate the immune system to attack tumors and are therefore used to treat cancer. |
| Host | Mouse |
| Immunogen | Native PD-1 protein |
| Subclass | IgG1 |
| Research Area | Cancer, Cell Signaling & Signal Transduction, Immunology |
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