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|Cellular/Tissue Localisation||Expressed in neurons and a paraneoplastic antigen expressed in neuroendocrine tumours|
|Storage||Store at 4ºC; longterm storage at -20ºC|
|Antigen/Gene or Protein Targets||HuD|
|Notes||Expressed in E.coli as a 6his and MBP fusion protein and purified by MBP-tag affinity chromatography|
HuD otherwise known as ELAV-like protein 4 is a protein that in humans is encoded by the ELAVL4 gene. The HuD/ELAVL4 protein is an RNA-binding protein.
HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.
HuD was originaly discovered as the paraneoplastic antigen expressed in neuroendocrine tumors. Recombinant HuD was first used to assay the presence of anti-Hu antibodies and thereby diagnose the presence of small cell lung cancer and subacute sensory neuronopathy.
|Research Area||Cancer, Developmental Biology, Gene Expression, Neurobiology|
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