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Anti-Lamin B receptor [BB3SS4B5]

Info

Catalogue Number 153491
Applications IHC IF WB
Antigen/Gene or Protein Targets Lamin B receptor
Synonyms DHCR 14B antibody, DHCR14B antibody, Integral nuclear envelope inner membrane protein antibody, Lamin-B receptor antibody, LBR antibody, LBR_HUMAN antibody, LMN 2R antibody, LMN2R antibody, MGC9041 antibody, PHA antibody, PRO0650 antibody
Reactivity Human and Mouse
Relevance Lamin B Receptor (LBR) is a polytopic inner nuclear membrane protein. Its nucleoplasmic domain interacts with components of the nuclear lamina as well as with chromatin, via HP1. LBR also exhibits C14 sterol reductase activity. Deficiency of LBR in humans results in Pelget-Hu√ęt anomaly featuring hypolobulated granulocyte nuclei. Homozygous loss of LBR causes Greenberg skeletal dysplasia a fetal lethal disorder associated with defective cholesterol metabolism.
Host Mouse
Immunogen GST fused to N-terminal fragment of human LBR (amino acids residues 1-211)
Subclass IgG1 kappa
Positive Control Hela, C2C12, NIE-115
Myeloma Used Sp2/0-Ag14
Strain C57BL/6
Notes Hybridoma cell line monoclonality was achieved by single cell sorting using flow cytometry. Human LBR is 70,7kDa and mouse is 71.4kDa. Entrez Gene Number is 3930. Gene symbol is LBR. UniProt Number is Q14739. Immunohistochemistry: paraffin-embedded section, cryosections. Immunocytochemistry/Immunofluorescence: formaldehyde, methanol fixation with methanol fixation resulting in a brighter signal.
Research Area Cell Signaling & Signal Transduction

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