Log in Register
Menu

Anti-Lamin A+C [WL4G10]

Info

Catalogue Number 153490
Applications IHC IF WB
Antigen/Gene or Protein Targets Lamin A and Lamin C
Synonyms 71 kDa lamin antibody, Cardiomyopathy dilated 1A (autosomal dominant) antibody, CDCD1 antibody, CDDC antibody, CMD1A antibody, CMT2B1 antibody, EMD2 antibody, FPL antibody, FPLD antibody, FPLD2 antibody, HGPS antibody, IDC antibody, Lamin A antibody, Lamin A/C antibody, Lamin A/C like 1 antibody, Lamin antibody, Lamin C antibody, Lamin-A/C antibody, LDP1 antibody
Reactivity Human
Relevance Lamins A and C are major components of the nuclear lamina, a thin protein meshwork located at the nuclear face of the nuclear envelope (NE). The lamina provides structural integrity to the NE and is involved in many other aspects of nuclear biology including transcription and chromatin organization. Lamins A and C arise from the LMNA gene by alternative splicing and majority of adult tissues express at least one of the isoform. The LMNA gene has been extensively studies due to its association with variety of human diseases. Mutations in LMNA have been linked 12 distinct disorders, including Emery-Dreifus muscular dystrophy, dilated cardiomyopathy, Dunnigan-type partial lipodystrophy and Hutchinson-Gilford progeria syndrome.
Host Mouse
Immunogen GST fused to C-terminal fragment of human lamin A (amino acids residues 422-664)
Subclass IgG1 kappa
Positive Control Hela, 293T
Myeloma Used Sp2/0-Ag14
Strain C57BL/6
Notes Lamin A is 74kDa and Lamin C is 65 kDa. Entrez Gene Number is 4000. Gene symbol is LMNA. UniProt Number is P02545. Immunohistochemistry: paraffin-embedded section, cryosections. Immunocytochemistry/Immunofluorescence: formaldehyde, methanol fixation.
Research Area Cell Signaling & Signal Transduction

References: 0 entry

There is no reference for this reagent yet, feel free to use the button below to suggest one.

Add a reference

References: 0 entry

There is no reference for this reagent yet, feel free to use the button below to suggest one.

Add a reference

References: 0 entry

There is no reference for this reagent yet, feel free to use the button below to suggest one.

Add a reference


This reagent does not have any reviews at the moment.