Cancer Research Technology
Log in Register
Menu

Anti-SUN2 [3.1E]

Invented at A*STAR Accelerate Technologies Pte Ltd

Info

Catalogue Number 153484
Applications IF WB
Antigen/Gene or Protein Targets SUN-2
Synonyms FRIGG antibody, KIAA0668 antibody, Nuclear envelope protein antibody, Protein unc-84 homolog B antibody, Rab5 interacting protein antibody, RAB5IP antibody, Sad1 and UNC84 domain containing 2 antibody, Sad1 unc-84 domain protein 2 antibody, Sad1 unc84 domain protein antibody, Sad1/unc-84 protein-like 2 antibody, Sad1/unc84 protein-like antibody
Reactivity Mouse and Rat
Relevance A notable feature of metazoan cells is their morphological plasticity associated with acquisition of a range of complex activities. Implementation of numerous specialized functions during differentiation is dependent upon the rearrangement and transformation of organelles, including the cell nucleus. Crucial to many cell specific changes in nuclear localization and organization is establishment of connections between the nucleus and cytoskeleton. Such connections are formed in part by KASH-domain proteins of the outer nuclear membrane (ONM). In mammals six KASH proteins are known (Nesprins 1, 2, 3, 4, LRMP and KASH5). Appropriate localization of KASH proteins is dependent upon tethering in the ONM by SUN-domain proteins of the inner nuclear membrane. Together, SUN-KASH pairs form LINC complexes (LInker of the Nucleoskeleton and Cytoskeleton) that span both nuclear membranes and which couple nuclear structures to the cytoskeleton. In recent years it has become apparent that LINC complex defects may contribute to a number of human genetic diseases,
including muscular dystrophy, cerebellar ataxia, hearing loss and infertility.

In mammals the SUN protein family consists of at least 5 members. Sun1 and Sun2 share a high degree of homology and are ubiquitously expressed. Sun3-5 are more distantly related to Sun1-2 and have limited tissue expression.
Host Mouse
Immunogen Glutathione-S-transferase (GST) fused to residues 1-121 of human SUN2.
Immunogen UniProt ID Q9UH99
Positive Control Hela, C2C12, U2O2, fibroblasts
Subclass IgG2a kappa
Myeloma Used Sp2/0-Ag14
Strain C57BL/6
Notes Specificity: The antibody recognizes Sun2, it does not recognize Sun1
Epitope: Not known

Entrez Gene Number: 25777
Gene Symbol: FRIGG, KIAA0668, RAB5IP, UNC84B
UniProt Number: Q9UH99
Research Area Cell Signaling & Signal Transduction, Developmental Biology

References

There are 0 reference entries for this reagent.

References: 0 entry

There is no reference for this reagent yet, feel free to use the button below to suggest one.

Add a reference

References: 0 entry

There is no reference for this reagent yet, feel free to use the button below to suggest one.

Add a reference

Inventor Information

No inventors are currently linked to this reagent.

Add an inventor