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Anti-SUN1 [12.10F]

Info

Catalogue Number 153483
Applications IF WB
Antigen/Gene or Protein Targets SUN-1
Synonyms Protein unc-84 homolog A antibody, Sad1 and UNC84 domain containing 1 antibody, Sad1/unc 84 protein like 1 antibody, Sad1/unc-84 protein-like 1 antibody, Sun domain-containing protein 1 antibody, Sun1 antibody, SUN1_HUMAN antibody
Reactivity Mouse and Rat
Relevance A notable feature of metazoan cells is their morphological plasticity associated with acquisition of a range of complex activities. Implementation of numerous specialized functions during differentiation is dependent upon the rearrangement and transformation of organelles, including the cell nucleus. Crucial to many cell specific changes in nuclear localization and organization is establishment of connections between the nucleus and cytoskeleton. Such connections are formed in part by KASH-domain proteins of the outer nuclear membrane (ONM). In mammals six KASH proteins are known (Nesprins 1, 2, 3, 4, LRMP and KASH5). Appropriate localization of KASH proteins is dependent upon tethering in the ONM by SUN-domain proteins of the inner nuclear membrane. Together, SUN-KASH pairs form LINC complexes (LInker of the Nucleoskeleton and Cytoskeleton) that span both nuclear membranes and which couple nuclear structures to the cytoskeleton. In recent years it has become apparent that LINC complex defects may contribute to a number of human genetic diseases,
including muscular dystrophy, cerebellar ataxia, hearing loss and infertility.

Sun1 is one of at least five mammalian SUN protein family members and is ubiquitously expressed. Of note, Sun1 undergoes extensive alternative splicing. Human and mouse tissues express simultaneously several isoforms with the presence and prevalence of specific isoforms being tissue dependent.
Host Mouse
Immunogen GST fused to residues encoded by exons 6, 8, 10
Immunogen UniProt ID Q9D666
Positive Control C2C12, mouse fibroblast
Subclass IgG2a kappa
Molecular Weight (kDa) 102
Myeloma Used Sp2/0-Ag14
Strain C57BL/6
Notes Species Reactivity: Mouse, does not react with human; not tested with other species
Epitope: Not known
Knock Out Validated

Entrez Gene Number: 77053
Gene Symbol: KIAA0810, UNC84A
UniProt Number: Q9D666
Molecular Weight: Mouse 102 kDa; existence of multiple shorter isoforms
Research Area Cell Signaling & Signal Transduction, Developmental Biology

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