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- Inventor Info
|Antigen/Gene or Protein Targets||Leukocyte-associated immunoglobulin-like receptor-1|
|Synonyms||Leukocyte-associated immunoglobulin-like receptor-1, LAIR-1, LAIR1, CD305, cluster of differentiation 305,|
Leukocyte-associated immunoglobulin-like receptor-1, or LAIR-1, is a collagen receptor expressed on hematopoietic cells which can differentiate to peripheral mononuclear cells like NK, T and B cells. LAIR-1 is also expressed on immature megakaryocytes but undetectable on platelets, the physiological role that LAIR-1 plays on megakaryocytes and platelet formation is currently poorly understood.
LAIR-1 belongs to the inhibitory immunoreceptor tyrosine-based inhibition motif–containing receptor family. The inhibitory receptor regulates the immune response preventing lysis of cells recognized as self. LAIR-1 inhibits signalling via the immunoreceptor tyrosine-based activation motif-containing receptor complex, glycoprotein VI-FcRγ-chain.
The gene which encodes LAIR-1 is encoded in the leukocyte receptor cluster which also encodes at least 29 other genes encoding leukocyte-expressed receptors from the immunoglobulin superfamily.
LAIR-1 is known to interact with PTPN11 and PTPN6.
|Breeding Information||The mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.|
|Conditional Description||The proximal promoter and exons 1 and 2 of LAIR-1 were replaced with a flanked positive puromycin selection cassette expressed under the control of a eukaryotic promoter and includes a polyadenylation signal. Homologous recombinant clones were isolated using Puromycin resistance. The BAC targeting vector used was from the C57BL/6J RPCIB-731 BAC library and was transfected into the TaconicArtemis C57BL/6N Tac ES cell line. Removal of the promoter and exons 1 and 2 deletes the translation initiation codon and the sequence encoding the signal peptide. In addition the absence of the 5’UTR should also prevent transcription of the messenger RNA. Flp-mediated removal of the positive selection cassette also results in a constitutive KO allele.|
|Research Area||Cell Signaling & Signal Transduction, Immunology|
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