Anti-IgM [Z69]
Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited
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Info
![Western blot image showing positive detection of IgM in Meagre serum using Anti-IgM [Z69]. 1:5 dilution of supernatant.](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/30addbf6-65f3-4ef4-9260-1ce95e7e7c63.png)
![Western blot image showing positive detection of IgM in multiple species using Anti-IgM [Z69]. (1) Protein ladder, (2) Meagre serum 1:5 dilution, (3) Lumpsucker serum 1:5 dilution](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/0d37c753-74e3-4f11-be6f-ed50a3a97f8a.png)
![Immunohistochemistry was performed on formalin-fixed paraffin-embedded tissues. Positive membranous immunostaining is observed in infected trout kidney using Anti-IgM [Z69].](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/5aab3891-f6e1-4820-948a-79ad89d51f23.png)
![Western blot image showing positive detection of IgM in Meagre serum using Anti-IgM [Z69]. 1:5 dilution of supernatant.](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/30addbf6-65f3-4ef4-9260-1ce95e7e7c63.png)
![Western blot image showing positive detection of IgM in multiple species using Anti-IgM [Z69]. (1) Protein ladder, (2) Meagre serum 1:5 dilution, (3) Lumpsucker serum 1:5 dilution](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/0d37c753-74e3-4f11-be6f-ed50a3a97f8a.png)
![Immunohistochemistry was performed on formalin-fixed paraffin-embedded tissues. Positive membranous immunostaining is observed in infected trout kidney using Anti-IgM [Z69].](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/5aab3891-f6e1-4820-948a-79ad89d51f23.png)
![Image thumbnail for Anti-IgM [Z69]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/30addbf6-65f3-4ef4-9260-1ce95e7e7c63.png)
![Image thumbnail for Anti-IgM [Z69]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/0d37c753-74e3-4f11-be6f-ed50a3a97f8a.png)
![Image thumbnail for Anti-IgM [Z69]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/5aab3891-f6e1-4820-948a-79ad89d51f23.png)
| Catalogue Number | 153475 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | Immunoglobulin Heavy Constant Mu (IgM) |
| Synonyms |
IgM antibody IGHM antibody IgM heavy chain constant region antibody Immunoglobulin heavy constant mu antibody Immunoglobulin mu chain antibody Imunoglobulin heavy chain antibody Imunoglobulin heavy chain constant region mu antibody Imunoglobulin heavy chain mu constant region antibody MU antibody VH antibody |
| Reactivity | Meagre and Lumpsucker |
| Relevance |
Monoclonal antibody with use to monitor and develop vaccines in fish. Background and Research Application IgM is the largest antibody, and it is the first antibody to appear in the response to initial exposure to an antigen. Detection of specific antibodies in the serum of animals is an indicator of previous exposure to pathogens which is very valuable for brood stock health testing. This anti-IgM antibody provides a useful tool to monitor vaccine performance in fish and will assist in the development of future vaccines. |
| Host | Mouse |
| Immunogen | ovalbumin-conjugated synthetic peptide |
| Positive Control | Western Blot- fish sera; IHC- Formalin-fixed, paraffin-embedded head kidney, gill and spleen tissues |
| Subclass | IgG |
| Myeloma Used | P3X63Ag8.653 |
| Strain | Balb/c |
| Notes |
Production Details Purified using multi-step affinity chromatography with protein A. Storage Conditions Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles. Points of Interest Meagre (Argyrosomus regius) and Lumpsucker (Cyclopteridae) Concentration 1mg/ml as standard |
| Research Area | Aquaculture, Immunology |
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