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Anti-PIWIL3 [Z83]

Invented by Ayham Alnabulsi at Vertebrate Antibodies Limited

Info

Catalogue Number 153471
Applications ELISA IHC WB
Antigen/Gene or Protein Targets Piwi Like RNA-Mediated Gene Silencing 3
Synonyms Anti-PIWIL3 antibody, HIWI3 antibody, Piwi like 3 antibody, PIWL3_HUMAN antibody
Reactivity Human
Relevance PIWIL3 may play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. PIWIL3 acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. PIWIL3 directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs may be involved in other processes during meiosis such as translation regulation.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide PNRSLSTRLFYL- peptide immunogen is identical in primates
Positive Control IHC- formalin-fixed, paraffin-embedded multi tumour tissue microarray; Western Blot - Jurkat and Hela cell lysates
Subclass IgG
Myeloma Used P3X63Ag8.653
Strain Balb/c
Notes Recommended Usage Conditions: ELISA - neat, IHC- antigen retrieval: microwave 20 min @ 800W in 10 mM citrate buffer, pH 6.0; Western blot - 1 in 2 dilution
Research Area Developmental Biology, Epigenetics & Nuclear Signalling, Stem Cell Biology

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