| Catalogue Number | 153458 |
| Backbone Size (bp) | 3669 |
| Bacterial Resistance | Kanamycin |
| Vector Type | pRSF-1b |
| Synonyms | UBE2D2, E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B, ubiquitin conjugating enzyme E2 D2 |
| Antigen/Gene or Protein Targets | UbcH5B |
| Relevance |
Protein modification through ubiquitination is an important cellular mechanism to target abnormal or short-lived proteins for degradation. The process of ubiquitination involves three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes and ubiquitin-protein ligases. UbcH5B, encoded by the UBE2D2 gene, is a member of the E2 ubiquitin-conjugating enzyme family. UbcH5B is involved in the ubiquitination of p53 and two alternatively spliced transcript variants have been discovered which encode distinct isoforms. |
| Research Area | Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling |
Dou et al. 2012. Nat Struct Mol Biol. 19(9):876-83. PMID: 22902369.
BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer.
Europe PMC ID: 22902369
Dou et al. 2012. Nat Struct Mol Biol. 19(9):876-83. PMID: 22902369.
BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer.
