Cancer Research Technology
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Catalogue Number 153458
Backbone Size (bp) 3669
Bacterial Resistance Kanamycin
Vector Type pRSF-1b
Synonyms UBE2D2, E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B, ubiquitin conjugating enzyme E2 D2
Antigen/Gene or Protein Targets UbcH5B
Relevance Protein modification through ubiquitination is an important cellular mechanism to target abnormal or short-lived proteins for degradation. The process of ubiquitination involves three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes and ubiquitin-protein ligases.

UbcH5B, encoded by the UBE2D2 gene, is a member of the E2 ubiquitin-conjugating enzyme family. UbcH5B is involved in the ubiquitination of p53 and two alternatively spliced transcript variants have been discovered which encode distinct isoforms.
Research Area Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling

References

There are 2 reference entries for this reagent.

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References: 2 entries
RECENTLY UPDATED

Dou et al. 2012. Nat Struct Mol Biol. 19(9):876-83. PMID: 22902369.

BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer.

Europe PMC ID: 22902369


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References: 2 entries
RECENTLY UPDATED

Dou et al. 2012. Nat Struct Mol Biol. 19(9):876-83. PMID: 22902369.

BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer.


Add a reference