Anti-VHL [LIZ167C]
Invented at The Institute of Cancer Research
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Info
| Catalogue Number | 153442 |
| Antigen/Gene or Protein Targets | VHL |
| Synonyms | von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase |
| Relevance | VHL is Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. It is involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. |
| Research Area | Cancer, Cell Cycle, Epigenetics & Nuclear Signalling, Metabolism |
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