Anti-Keratin 19 [LP2K]
Invented by Prof Irene Leigh from Queen Mary University of London
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (6)
- Inventor Info
Info
| Catalogue Number | 153429 |
| Applications | IHC WB |
| Antigen/Gene or Protein Targets | Keratin 19 |
| Synonyms | 40 kDa keratin intermediate filament antibody, CK 19 antibody, CK-19 antibody, CK19 antibody, Cytokeratin 19 antibody, Cytokeratin-19 antibody, K19 antibody, K1C19_HUMAN antibody, K1CS antibody, Keratin 19 antibody, Keratin type I 40 kD antibody, Keratin type I 40kD antibody, Keratin type I cytoskeletal, 19 antibody, Keratin, type I cytoskeletal 19 antibody, Keratin type I 40 kd antibody, Keratin-19 antibody, KRT19 antibody, MGC15366 antibody |
| Reactivity | Human |
| Relevance | Keratin 19 was first detected in squamous cell carcinoma lines and it is identifiable by its characteristically low molecular weight on SDS gels at 40 kD. It is generally regarded as being characteristic of simple epithelia such as intestine, kidney collecting ducts, gallbladder, mesothelium, and glandular secretory cells. Keratin 19 has unusually wide tissue distribution, and has been reported to be present, in significant quantities and under apparently normal conditions, in both stratified and squamous epithelia. Keratin 19 is a tumour marker used to establish poor prognosis in several types of carcinoma including hepatocellular and NSCL. |
| Host | Mouse |
| Immunogen | Sonicated cytoskeleton fractions (material insoluble in 1% Nonidet-P40(N-P40)) from SVK14 cells (SV40-transformed human neonatalkeratinocytes: 19) |
| Molecular Weight (kDa) | 40 |
| Myeloma Used | Sp2/0-Ag14 |
| Strain | Balb/c |
| Research Area | Cancer, Cell Type or Organelle Marker |
References: 6 entries
Böttger et al. 1995. Eur J Biochem. 231(2):475-85. PMID: 7543411.
Epitope mapping of monoclonal antibodies to keratin 19 using keratin fragments, synthetic peptides and phage peptide libraries.
Europe PMC ID: 7543411
Fridmacher et al. 1992. Development. 115(2):503-17. PMID: 1385062.
Differential expression of acidic cytokeratins 18 and 19 during sexual differentiation of the rat gonad.
Europe PMC ID: 1385062
Stasiak et al. 1989. J Invest Dermatol. 92(5):707-16. PMID: 2469734.
Keratin 19: predicted amino acid sequence and broad tissue distribution suggest it evolved from keratinocyte keratins.
Europe PMC ID: 2469734
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References: 6 entries
Böttger et al. 1995. Eur J Biochem. 231(2):475-85. PMID: 7543411.
Epitope mapping of monoclonal antibodies to keratin 19 using keratin fragments, synthetic peptides and phage peptide libraries.
Fridmacher et al. 1992. Development. 115(2):503-17. PMID: 1385062.
Differential expression of acidic cytokeratins 18 and 19 during sexual differentiation of the rat gonad.
Stasiak et al. 1989. J Invest Dermatol. 92(5):707-16. PMID: 2469734.
Keratin 19: predicted amino acid sequence and broad tissue distribution suggest it evolved from keratinocyte keratins.
Add a reference
