Anti-HIV gp41 [SAR1] monoclonal antibody
Invented by Nigel Dimmock
Invented at University Of Warwick
- Datasheet
- References (3)
- Inventor Info
Info
| Catalogue Number | 153418 |
| Applications | ELISA Fn WB |
| Antigen/Gene or Protein Targets | HIV-1 gp41 tail sequence GERDRDR |
| Synonyms | Env antibody, Glycoprotein 41 antibody, gp41 antibody, Human Immunodeficiency Virus 1 antibody, TM antibody, Transmembrane protein antibody |
| Reactivity | Virus |
| Relevance | The envelope protein of human immunodeficiency virus type 1 (HIV-1) is synthesized as a gp160 polypeptide that is cleaved to form a non-covalently linked heterodimer; an external gp120 domain and a transmembrane anchoring gp41 domain. The monoclonal antibody SAR1 is a novel IgG that was raised by immunising mice with a plant virus chimera expressing the gp41 tail sequence GERDRDR. SAR1 recognizes gp41 expressed on the surface of infected cells, and binds to some, but not all, preparations of purified virions, suggesting that it may recognize non-infectious virions or degraded/immature forms of the envelope protein. SAR1 actively neutralized virus after it had attached to target cells but had little activity against free virions. Data suggest that SAR1 mediates post-attachment neutralization of virus bound to target cells by inhibiting virus-mediated fusion. |
| Host | Mouse |
| Immunogen | Mice were infected with Cowpea mosaic virus-HIV-1 gp41 chimera (30 g/ml) expressing the gp41 C-terminal sequence GERDRDR |
| Subclass | IgG2a kappa |
| Myeloma Used | Sp2/0-Ag14 |
| Research Area | Immunology, Virology |
References: 3 entries
Heap et al. 2005. J Gen Virol. 86(Pt 5):1499-507. PMID: 15831963.
Cheung et al. 2005. J Gen Virol. 86(Pt 1):131-8. PMID: 15604440.
Reading et al. 2003. Virology. 315(2):362-72. PMID: 14585339.
Add a reference
References: 3 entries
Heap et al. 2005. J Gen Virol. 86(Pt 5):1499-507. PMID: 15831963.
Cheung et al. 2005. J Gen Virol. 86(Pt 1):131-8. PMID: 15604440.
Reading et al. 2003. Virology. 315(2):362-72. PMID: 14585339.
Add a reference
Inventor Information
Inventors
|
Nigel Dimmock |
