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Anti-Phospho-Rb (Ser608) [51B7]

Info

Catalogue Number 153409
Applications IHC IF WB
Antigen/Gene or Protein Targets Rb (phospho Ser608)
Synonyms Retinoblastoma 1; RB1; p105-Rb; RB; pp110; pRb; OSRC
Reactivity Human and Mouse
Relevance Monoclonal antibody which detects the tumour suppressor Rb, when phosphorylated at residue Ser608.

Background and Research Application
Retinoblastoma protein (Rb) is a tumour suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. One function of Rb is to prevent excessive cell growth by inhibiting cell cycle progression. Rb is also a recruiter of several chromatin remodelling enzymes such as methylases and acetylases. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukaemia. Phosphorylation of Rb at S608 depends on CDK4.
Host Mouse
Immunogen Synthetic peptide C-ADMYLSPLRSPK phosphorylated at S608, conugated to KLH
Immunogen UniProt ID P06400
Subclass IgG1
Molecular Weight (kDa) 111
Notes Production Details
Purified using multi-step affinity chromatography with protein A.

Storage Conditions
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.

Concentration
1mg/ml as standard
Research Area Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, Immunology

References

There are 8 reference entries for this reagent.

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References: 8 entries

Wadosky et al. 2016. J Mol Endocrinol. 56(3):273-90. PMID: 26862156.

Silva et al. 2014. PLoS One. 9(6):e99897. PMID: 24936870.

Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease.

Europe PMC ID: 24936870

Shilkaitis et al. 2013. Cancer Prev Res (Phila). 6(4):299-308. PMID: 23430755.

Bettencourt-Dias et al. 2003. J Cell Sci. 116(Pt 19):4001-9. PMID: 12928330.

Barrie et al. 2003. Anal Biochem. 320(1):66-74. PMID: 12895470.

High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells.

Europe PMC ID: 12895470

Heterogeneous proliferative potential in regenerative adult newt cardiomyocytes.

Europe PMC ID: 12928330


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References: 8 entries

Wadosky et al. 2016. J Mol Endocrinol. 56(3):273-90. PMID: 26862156.

Silva et al. 2014. PLoS One. 9(6):e99897. PMID: 24936870.

Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease.

Shilkaitis et al. 2013. Cancer Prev Res (Phila). 6(4):299-308. PMID: 23430755.

Bettencourt-Dias et al. 2003. J Cell Sci. 116(Pt 19):4001-9. PMID: 12928330.

Barrie et al. 2003. Anal Biochem. 320(1):66-74. PMID: 12895470.

High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells.

Heterogeneous proliferative potential in regenerative adult newt cardiomyocytes.


Add a reference

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