Anti-Phospho-Rb (Ser608) [51B7]
Invented at The Institute of Cancer Research
- Datasheet
- References (8)
- Inventor Info
Info
| Catalogue Number | 153409 |
| Applications | IHC IF WB |
| Antigen/Gene or Protein Targets | Rb (phospho Ser608) |
| Synonyms | Retinoblastoma 1; RB1; p105-Rb; RB; pp110; pRb; OSRC |
| Reactivity | Human and Mouse |
| Relevance |
Monoclonal antibody which detects the tumour suppressor Rb, when phosphorylated at residue Ser608. Background and Research Application Retinoblastoma protein (Rb) is a tumour suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. One function of Rb is to prevent excessive cell growth by inhibiting cell cycle progression. Rb is also a recruiter of several chromatin remodelling enzymes such as methylases and acetylases. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukaemia. Phosphorylation of Rb at S608 depends on CDK4. |
| Host | Mouse |
| Immunogen | Synthetic peptide C-ADMYLSPLRSPK phosphorylated at S608, conugated to KLH |
| Immunogen UniProt ID | P06400 |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 111 |
| Notes |
Production Details Purified using multi-step affinity chromatography with protein A. Storage Conditions Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles. Concentration 1mg/ml as standard |
| Research Area | Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, Immunology |
References: 8 entries
Wadosky et al. 2016. J Mol Endocrinol. 56(3):273-90. PMID: 26862156.
Silva et al. 2014. PLoS One. 9(6):e99897. PMID: 24936870.
Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease.
Europe PMC ID: 24936870
Shilkaitis et al. 2013. Cancer Prev Res (Phila). 6(4):299-308. PMID: 23430755.
Bettencourt-Dias et al. 2003. J Cell Sci. 116(Pt 19):4001-9. PMID: 12928330.
Barrie et al. 2003. Anal Biochem. 320(1):66-74. PMID: 12895470.
High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells.
Europe PMC ID: 12895470
Heterogeneous proliferative potential in regenerative adult newt cardiomyocytes.
Europe PMC ID: 12928330
Add a reference
References: 8 entries
Wadosky et al. 2016. J Mol Endocrinol. 56(3):273-90. PMID: 26862156.
Silva et al. 2014. PLoS One. 9(6):e99897. PMID: 24936870.
Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease.
Shilkaitis et al. 2013. Cancer Prev Res (Phila). 6(4):299-308. PMID: 23430755.
Bettencourt-Dias et al. 2003. J Cell Sci. 116(Pt 19):4001-9. PMID: 12928330.
Barrie et al. 2003. Anal Biochem. 320(1):66-74. PMID: 12895470.
High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells.
Heterogeneous proliferative potential in regenerative adult newt cardiomyocytes.
Add a reference
