Anti-Phospho-Raf1 (Ser338) [DPR/2/2A/3A]
Invented at The Institute of Cancer Research
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 153408 |
| Applications | WB |
| Antigen/Gene or Protein Targets | Raf-1 |
| Synonyms | RAF1; Raf-1; c-Raf; NS5; CRAF; v-raf-1 murine leukemia viral oncogene homolog 1 |
| Reactivity | Human |
| Relevance | This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. |
| Host | Rat |
| Immunogen | Synthetic peptide GQRDpSSYpYWEIEAS coupled to glutaraldehyde |
| Subclass | IgG1 |
| Research Area | Cancer, Immunology |
References: 4 entries
Chiloeches et al. 2001. Mol Cell Biol. 21(7):2423-34. PMID: 11259591.
S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3.
Europe PMC ID: 11259591
Mason et al. 1999. EMBO J. 18(8):2137-48. PMID: 10205168.
Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.
Europe PMC ID: 10205168
Add a reference
References: 4 entries
Chiloeches et al. 2001. Mol Cell Biol. 21(7):2423-34. PMID: 11259591.
S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3.
Mason et al. 1999. EMBO J. 18(8):2137-48. PMID: 10205168.
Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.
Add a reference
