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Anti-Phospho-Raf1 (Ser338) [DPR/2/2A/3A]

Info

Catalogue Number 153408
Applications WB
Antigen/Gene or Protein Targets Raf-1
Synonyms RAF1; Raf-1; c-Raf; NS5; CRAF; v-raf-1 murine leukemia viral oncogene homolog 1
Reactivity Human
Relevance This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
Host Rat
Immunogen Synthetic peptide GQRDpSSYpYWEIEAS coupled to glutaraldehyde
Subclass IgG1
Research Area Cancer, Immunology

References

There are 4 reference entries for this reagent.

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References: 4 entries

Chiloeches et al. 2001. Mol Cell Biol. 21(7):2423-34. PMID: 11259591.

S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3.

Europe PMC ID: 11259591

Mason et al. 1999. EMBO J. 18(8):2137-48. PMID: 10205168.

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.

Europe PMC ID: 10205168


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References: 4 entries

Chiloeches et al. 2001. Mol Cell Biol. 21(7):2423-34. PMID: 11259591.

S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3.

Mason et al. 1999. EMBO J. 18(8):2137-48. PMID: 10205168.

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.


Add a reference

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