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Catalogue Number 153405
Applications IHC IP WB
Antigen/Gene or Protein Targets Human TP53 / p53
Synonyms p53
Reactivity Human
Relevance Mouse anti human p53 antibody, clone DO-14 recognizes the human cellular tumor antigen p53, also known as p53 tumour suppressor protein or NY-CO-13. p53 is a 393 amino acid ~53kDa cytoplasmic/ nuclear protein up-regulated in response to DNA damage and is found in a wide variety of transformed cells. DO-14 binds to an epitope within the central region of p53 between amino acids 110 - 286 defining a cryptic epitope exposed in unfolded/ denatured p53. Nine isoforms of human p53 are produced by alternative splicing and promotor usage, the epitope recognized by clone DO-14 is present in all isoforms.
Host Mouse
Immunogen Recombinant human p53
Immunogen UniProt ID P53_HUMAN
Subclass IgG1
Molecular Weight (kDa) 53
Research Area Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, Immunology

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