Anti-p53 [DO-13]
Invented by Prof David Lane from A*STAR Accelerate Technologies Pte Ltd
Invented at University of Dundee
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 153404 |
| Applications | IHC IP WB |
| Antigen/Gene or Protein Targets | Human TP53 / p53 |
| Synonyms | p53 |
| Reactivity | Human |
| Relevance | Mouse anti human p53 antibody, clone DO-13 recognizes the human cellular tumor antigen p53, also known as p53 tumour suppressor protein or NY-CO-13. p53 is a 393 amino acid ~53kDa cytoplasmic/ nuclear protein up-regulated in response to DNA damage and is found in a wide variety of transformed cells. DO-13 binds to an epitope between amino acids 26-35.. Nine isoforms of human p53 are produced by alternative splicing and promotor usage, the epitope recognized by clone DO-13 is present in all isoforms. |
| Host | Mouse |
| Immunogen | Recombinant human p53 |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 53 |
| Research Area | Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, Immunology |
References: 2 entries
Hsieh et al. 2002. Mol Cell Biol. 22(1):78-93. PMID: 11739724.
Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage.
Europe PMC ID: 11739724
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References: 2 entries
Hsieh et al. 2002. Mol Cell Biol. 22(1):78-93. PMID: 11739724.
Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage.
Add a reference
