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Anti-p53 [DO-13]

Invented by Prof David Lane at University of Dundee

Info

Catalogue Number 153404
Applications IHC IP WB
Antigen/Gene or Protein Targets Human TP53 / p53
Synonyms p53
Reactivity Human
Relevance Mouse anti human p53 antibody, clone DO-13 recognizes the human cellular tumor antigen p53, also known as p53 tumour suppressor protein or NY-CO-13. p53 is a 393 amino acid ~53kDa cytoplasmic/ nuclear protein up-regulated in response to DNA damage and is found in a wide variety of transformed cells. DO-13 binds to an epitope between amino acids 26-35.. Nine isoforms of human p53 are produced by alternative splicing and promotor usage, the epitope recognized by clone DO-13 is present in all isoforms.
Host Mouse
Immunogen Recombinant human p53
Subclass IgG1
Molecular Weight (kDa) 53
Research Area Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, Immunology

References

There are 2 reference entries for this reagent.

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References: 2 entries

Hsieh et al. 2002. Mol Cell Biol. 22(1):78-93. PMID: 11739724.

Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage.

Europe PMC ID: 11739724


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References: 2 entries

Hsieh et al. 2002. Mol Cell Biol. 22(1):78-93. PMID: 11739724.

Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage.


Add a reference