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Catalogue Number 153403
Applications IF WB
Antigen/Gene or Protein Targets Human TP53 / p53
Synonyms p53
Reactivity Human
Relevance Mouse anti Human p53 antibody, clone DO-12 recognizes the human Cellular tumor antigen p53, also known as p53 tumour suppressor protein or NY-CO-13. p53 is a 393 amino acid ~53kDa cytoplasmic/ nuclear protein up-regulated in response to DNA damage and is found in a wide variety of transformed cells. DO-12 binds to an epitope epitope between aa 250 and 270, which is located between conserved domain IV and V on an exposed turn of the protein structure. Nine isoforms of human p53 are produced by alternative splicing and promotor usage, the epitope recognized by clone DO-12 is present in all isoforms.
Host Mouse
Immunogen Recombinant human p53
Subclass IgG1
Molecular Weight (kDa) 53
Research Area Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, Immunology

References

There are 4 reference entries for this reagent.

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References: 4 entries

Fujita et al. 2009. Nat Cell Biol. 11(9):1135-42. PMID: 19701195.

p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence.

Europe PMC ID: 19701195

Bourdon et al. 2005. Genes Dev. 19(18):2122-37. PMID: 16131611.

p53 isoforms can regulate p53 transcriptional activity.

Europe PMC ID: 16131611


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References: 4 entries

Fujita et al. 2009. Nat Cell Biol. 11(9):1135-42. PMID: 19701195.

p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence.

Bourdon et al. 2005. Genes Dev. 19(18):2122-37. PMID: 16131611.

p53 isoforms can regulate p53 transcriptional activity.


Add a reference