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Anti-MUC1 [C789]

Info

Catalogue Number 153397
Applications IHC
Antigen/Gene or Protein Targets MUC1
Synonyms CD227; KL6; Mucin 1; PEMT
Reactivity Human and Xenopus laevis
Relevance MUC1/CA 15-3 is used as a serological clinical marker of breast cancer to monitor response to breast cancer treatment and disease recurrence. Decreased levels over time may be indicative of a positive response to treatment. Conversely, increased levels may indicate disease progression. At an early stage disease, only 21% of patients exhibit high MUC1/CA 15-3 levels, that is why CA 15-3 is not a useful screening test. Most antibodies target the highly immunodominant core peptide domain of 20 amino acid (APDTRPAPGSTAPPAHGVTS) tandem repeats. Some antibodies recognize glycosylated epitopes. Medullary cystic kidney disease 1.
Host Mouse
Immunogen need access to this paper to answer this - https://www.ncbi.nlm.nih.gov/pubmed/?term=fine+specificity+of+antibody+recognition+of+carcinoma-associated+epithelial+musincs
Molecular Weight (kDa) 122
Research Area Cancer, Cell Cycle, Epigenetics & Nuclear Signalling

References

There are 2 reference entries for this reagent.

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References: 2 entries

Croce et al. 1997. Anticancer Res. 17(6D):4287-92. PMID: 9494522.

Expression of tumour associated antigens in normal, benign and malignant human mammary epithelial tissue: a comparative immunohistochemical study.

Europe PMC ID: 9494522


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References: 2 entries

Croce et al. 1997. Anticancer Res. 17(6D):4287-92. PMID: 9494522.

Expression of tumour associated antigens in normal, benign and malignant human mammary epithelial tissue: a comparative immunohistochemical study.


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