Anti-MUC1 [C789]
Invented at University of Nottingham
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 153397 |
| Applications | IHC |
| Antigen/Gene or Protein Targets | MUC1 |
| Synonyms | CD227; KL6; Mucin 1; PEMT |
| Reactivity | Human and Xenopus laevis |
| Relevance | MUC1/CA 15-3 is used as a serological clinical marker of breast cancer to monitor response to breast cancer treatment and disease recurrence. Decreased levels over time may be indicative of a positive response to treatment. Conversely, increased levels may indicate disease progression. At an early stage disease, only 21% of patients exhibit high MUC1/CA 15-3 levels, that is why CA 15-3 is not a useful screening test. Most antibodies target the highly immunodominant core peptide domain of 20 amino acid (APDTRPAPGSTAPPAHGVTS) tandem repeats. Some antibodies recognize glycosylated epitopes. Medullary cystic kidney disease 1. |
| Host | Mouse |
| Immunogen | need access to this paper to answer this - https://www.ncbi.nlm.nih.gov/pubmed/?term=fine+specificity+of+antibody+recognition+of+carcinoma-associated+epithelial+musincs |
| Molecular Weight (kDa) | 122 |
| Research Area | Cancer, Cell Cycle, Epigenetics & Nuclear Signalling |
References: 2 entries
Croce et al. 1997. Anticancer Res. 17(6D):4287-92. PMID: 9494522.
Expression of tumour associated antigens in normal, benign and malignant human mammary epithelial tissue: a comparative immunohistochemical study.
Europe PMC ID: 9494522
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References: 2 entries
Croce et al. 1997. Anticancer Res. 17(6D):4287-92. PMID: 9494522.
Expression of tumour associated antigens in normal, benign and malignant human mammary epithelial tissue: a comparative immunohistochemical study.
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