Anti-MUC1 [C595 (NCRC48)]
Invented at University of Nottingham
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 153396 |
| Applications | ELISA FACS IHC WB |
| Antigen/Gene or Protein Targets | MUC1 |
| Synonyms | CD227; KL6; Mucin 1; PEMT |
| Reactivity | Human |
| Relevance | MUC1/CA 15-3 is used as a serological clinical marker of breast cancer to monitor response to breast cancer treatment and disease recurrence. Decreased levels over time may be indicative of a positive response to treatment. Conversely, increased levels may indicate disease progression. At an early stage disease, only 21% of patients exhibit high MUC1/CA 15-3 levels, that is why CA 15-3 is not a useful screening test. Most antibodies target the highly immunodominant core peptide domain of 20 amino acid (APDTRPAPGSTAPPAHGVTS) tandem repeats. Some antibodies recognize glycosylated epitopes. Medullary cystic kidney disease 1. |
| Host | Mouse |
| Immunogen | Urinary MUC-1 mucin (Human) |
| Positive Control | Breast carcinoma |
| Subclass | IgG3 |
| Molecular Weight (kDa) | 122 |
| Research Area | Cancer, Cell Cycle, Epigenetics & Nuclear Signalling |
References: 4 entries
Yew et al. 2013. PLoS One. 8(9):e72637. PMID: 24039787.
Epimorphin-induced MET sensitizes ovarian cancer cells to platinum.
Europe PMC ID: 24039787
Guimaraes-Souza et al. 2012. Nephrol Dial Transplant. 27(8):3082-90. PMID: 22287659.
In vitro reconstitution of human kidney structures for renal cell therapy.
Europe PMC ID: 22287659
Add a reference
References: 4 entries
Yew et al. 2013. PLoS One. 8(9):e72637. PMID: 24039787.
Epimorphin-induced MET sensitizes ovarian cancer cells to platinum.
Guimaraes-Souza et al. 2012. Nephrol Dial Transplant. 27(8):3082-90. PMID: 22287659.
In vitro reconstitution of human kidney structures for renal cell therapy.
Add a reference
