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Anti-MCM2 [CRCT2.1]

Info

Catalogue Number 153395
Applications IHC WB
Antigen/Gene or Protein Targets MCM2
Synonyms MCM 2; CCNL1; CDCL1
Reactivity Human
Relevance The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM4 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the postreplicative state of the cell. MCM2/MCM4 complexes function as substrates for Cdc2/cyclin B in vitro. Cleavage of MCM3, which can be prevented by caspase inhibitors, results in the inactivation of the MCM complex (composed of at least MCM proteins 2-6) during apoptosis. A complex composed of MCM4, MCM6 and MCM7 has been shown to be involved in DNA helicase activity; and MCM5 is involved in IFN-γ-induced Stat1 transcription activation.
Host Mouse
Immunogen Bacterially expressed human MCM2
Positive Control HeLa nuclear extract lysate
Subclass IgG1
Molecular Weight (kDa) 130
Myeloma Used Sp2/0-Ag14
Research Area Epigenetics & Nuclear Signalling

References

There are 2 reference entries for this reagent.

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References: 2 entries

Giaginis et al. 2009. Dig Dis Sci. 54(2):282-91. PMID: 18465232.

Clinical significance of MCM-2 and MCM-5 expression in colon cancer: association with clinicopathological parameters and tumor proliferative capacity.

Europe PMC ID: 18465232


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References: 2 entries

Giaginis et al. 2009. Dig Dis Sci. 54(2):282-91. PMID: 18465232.

Clinical significance of MCM-2 and MCM-5 expression in colon cancer: association with clinicopathological parameters and tumor proliferative capacity.


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