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Anti-EGFR [ICR11]

Info

Catalogue Number 153387
Applications FACS IHC IP
Antigen/Gene or Protein Targets EGFR
Synonyms ERBB1; HER1; epidermal growth factor receptor; ERBB; mENA; PIG61
Reactivity Human
Relevance The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
Host Rat
Immunogen Squamous cell carcinoma
Subclass IgG2a
Molecular Weight (kDa) 42.4
Research Area Cancer, Cell Signaling & Signal Transduction

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